Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene. [5] TAK1 is an evolutionarily conserved kinase in the MAP3 K family and clusters with the tyrosine-like and sterile kinase families.

2024年12月25日 · MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7) is a Protein Coding gene. Diseases associated with MAP3K7 include Cardiospondylocarpofacial Syndrome and Frontometaphyseal Dysplasia 2. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Bacterial infections in CF airways.

Mitogen‐activated protein 3 kinase 7 (MAP3K7) encodes the ubiquitously expressed transforming growth factor β‐activated kinase 1, which plays a crucial role in many cellular processes. Mutationsin the MAP3K7 gene have been linked to two distinct ...

Mitogen-activated protein 3 kinase 7 (MAP3K7) encodes the ubiquitously expressed transforming growth factor β-activated kinase 1, which plays a crucial role in many cellular processes. Mutationsin the MAP3K7 gene have been linked to two distinct disorders: frontometaphyseal dysplasia type 2 (FMD2) a …

MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic Escherichia coli exposure. Enhanced expression of mRNA for transforming growth factor beta activated kinase 1 in CD34+ cells of the bone marrow in rheumatoid arthritis.

Heterozygous variants in MAP3K7, encoding the transforming growth factor-β-activated kinase 1 (TAK1), are associated with the ultrarare cardiospondylocarpofacial syndrome (CSCFS). Specific gain-of-function variants in the same gene cause the allelic frontometaphyseal dysplasia type 2.

2025年2月8日 · Insights into the molecular pathogenesis of cardiospondylocarpofacial syndrome: MAP3K7 c.737-7A > G variant alters the TGFβ-mediated α-SMA cytoskeleton assembly and autophagy.

2025年2月8日 · MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic Escherichia coli exposure. TAK1 protein kinase activity is required for TLR signalling …

2022年2月4日 · HGNC Approved Gene Symbol: MAP3K7. Cytogenetic location: 6q15 Genomic coordinates (GRCh38) : 6:90,513,579-90,587,072 (from NCBI) The MAP kinase (MAPK) cascades constitute functional units that couple upstream input signals to a variety of outputs through pathways that involve 3 protein kinases.

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway 1, 2, 3, 4, 5, 6, 7, 8. Plays an important role in the cascades of cellular responses evoked by changes in the environment 9, 10, 11, 12, 13, 14, 15, 16.