2024年12月25日 · Complete information for MACF1 gene (Protein Coding), Microtubule Actin Crosslinking Factor 1, including: function, proteins, disorders, pathways, orthologs, and expression.

Microtubule-actin crosslinking factor 1 (MACF1), also known as actin crosslinking factor 7 (ACF7), is essential for proper modulation of actin and microtubule cytoskeletal networks. Most MACF1 isoforms are expressed broadly in the body, but some …

2025年2月9日 · MACF1 comprises different isoforms, and is broadly expressed in brain, spinal cord, lung, kidney, heart, bone and skeletal muscles tissues. It plays a crucial role in cell proliferation, migration and cell signaling, and is also closely associated with many cancer.

MACF1 is one versatile spectraplakin with various functions in cell processes, embryo development, tissue-specific functions, and human diseases. The importance of MACF1 has become more apparent in recent years.

2023年6月23日 · Microtubule actin crosslinking factor 1 (MACF1) is a giant cytoskeletal crosslinking protein that can coordinate the different aspects of the mammalian cytoskeleton with a wide variety of...

2019年2月14日 · HGNC Approved Gene Symbol: MACF1. Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38) : 1:39,084,167-39,487,138 (from NCBI) ACF7 is a member of the spectraplakin family of cytoskeletal cross-linking proteins that possess actin- and microtubule-binding domains (Kodama et al., 2003).

Here, we describe the microtubule-associated protein, MACF1, as an essential and evolutionary conserved regulator of myonuclei positioning and maintenance, in cultured mammalian myotubes, in Drosophila muscle, and in adult mammalian muscle using a conditional muscle-specific knockout mouse model.

As a member of spectraplakin family of cytoskeletal crosslinking proteins, microtubule-actin crosslinking factor 1 (MACF1) controls cytoskeleton network dynamics. Knockout of Macf1 in mice resulted in the developmental retardation and embryonic lethality.

This study reveals that MACF1, a cytoskeletal protein, acts as a sponge for repressors of osteoblast differentiation to promote osteoblast differentiation and contributes to a novel mechanistic insight of osteoblast differentiation and transcription dynamics.

2024年2月12日 · Role of microtubule actin crosslinking factor 1 (MACF1) in bipolar disorder pathophysiology and potential in lithium therapeutic mechanism. Salem D, Fecek RJSalem D, et al. Transl Psychiatry, 2023 Jun 23.