MUC5B Gene - GeneCards | MUC5B Protein | MUC5B Antibody
2024年12月25日 · MUC5B (Mucin 5B, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC5B include Interstitial Lung Disease 2 and Extrinsic Allergic …
Muc5b overexpression causes mucociliary dysfunction and
2018年12月18日 · Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in …
MUC5B and Idiopathic Pulmonary Fibrosis - PMC - PubMed …
Idiopathic pulmonary fibrosis (IPF), a fatal disease that is a result of complex interactions between genetics and the environment, has limited treatment options. We have identified the MUC5B …
MUC5B - The New England Journal of Medicine
2018年10月20日 · The common gain-of-function variant rs35705950 16 in the promoter of MUC5B, encoding mucin 5B, is the strongest genetic risk factor for idiopathic pulmonary …
MUC5B mobilizes and MUC5AC spatially aligns mucociliary
2022年11月25日 · Airway mucus is composed of two mucins: mucin 5B (MUC5B) and 5AC (MUC5AC). Together, they form a hydrogel that can be actively transported by cilia along the …
Muc5b is required for airway defence - Nature
2013年12月8日 · Here we show that mouse Muc5b (but not Muc5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis …
MUC5B mucin 5B, oligomeric mucus/gel-forming [ (human)]
2025年2月8日 · MUC5B is a novel prognostic biomarker for patients with non-small cell lung cancer (NSCLC)carrying EGFR mutations but not for patients with NSCLC carrying wild-type …
MUC5B - an overview | ScienceDirect Topics
MUC5B, the major component, codes for a protein of 3570 amino acids, containing tandem repeats consisting of four superrepeats of 528 residues each (Desseyn et al. 1997), and is …
The MUC5B mucin polymer is dominated by repeating structural …
2019年11月22日 · The polymeric mucin MUC5B provides the structural and functional framework of respiratory mucus, conferring both viscoelastic and antimicrobial properties onto this vital …
Muc5b overexpression causes mucociliary dysfunction and …
2018年12月18日 · Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in …
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