DNA mismatch repair protein Mlh1 or MutL protein homolog 1 is a protein that in humans is encoded by the MLH1 gene located on chromosome 3. The gene is commonly associated with …

2023年7月12日 · If you both have a mutation in the MLH1 gene, there’s a chance your child could be born with a rare but serious condition called Constitutional Mismatch Repair Deficiency …

The MLH1 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps fix errors that are made when DNA is copied (DNA replication) in …

2024年12月25日 · MLH1 is a tumor suppressor gene involved in DNA mismatch repair. Germline mutations in this gene are known to cause Lynch syndrome. The most common malignancies …

2022年8月23日 · Studies show that men and women with an MLH1 mutation have between a 46 and 61 percent risk of developing colon or rectal cancer during their lifetime. Women with the …

2024年8月29日 · People with an MLH1 mutation who have been diagnosed with cancer may benefit from biomarker testing and may qualify for clinical trials looking for more effective …

2021年4月7日 · MLH1 gene encodes the MLH1 protein, which plays an essential role in postreplication DNA mismatch repair (Cell Res 2008;18:85) MLH1 forms a 2 protein complex …

2024年6月8日 · Lynch syndrome results from a germline mutation in 1 of 4 mismatch repair (MMR) genes: MLH1, MSH2, MSH6, and PMS2. Large deletions in a non-mismatch repair …

5 天之前 · People with an inherited MLH1 mutation have an increased risk for many cancers, especially of the large intestine (the colon and the rectum) and uterus (endometrium). Expert …

MLH1 is a gene that produces a protein involved in DNA repair, specifically in a process called mismatch repair. This protein works closely with other mismatch repair proteins, including …