2024年12月25日 · MAT1A (Methionine Adenosyltransferase 1A) is a Protein Coding gene. Diseases associated with MAT1A include Methionine Adenosyltransferase I/Iii Deficiency and Hypermethioninemia. Among its related pathways are methionine …

The MAT1A gene provides instructions for producing the enzyme methionine adenosyltransferase. The enzyme is produced from the MAT1A gene in two forms, designated MATI and MATII. MATI is made up of four identical protein subunits, which is …

Liver-specific isoenzyme MAT1A is genetically linked with an inborn metabolic disorder of hypermethioninemia, as well as a ubiquitously expressed isoenzyme MAT2A, whose enzymatic activity is regulated by an associated subunit MAT2B. Methionine adenosyltransferase I/III deficiency is caused by mutations in the MAT1A gene. (Review)

Methionine Adenosyltransferase 1A (MAT1A) is an enzyme which controls the production of S-adenosylmethionine (SAM) which functions as a methyl donor in the body, it is encoded for by the MAT1A gene.

2022年3月1日 · By using antisense oligonucleotides (ASO) and genetic depletion of Mat1a, here, we demonstrate that Mat1a deficiency in diet-induce obese or genetically obese mice prevented and reversed...

2024年12月10日 · Title: Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice.

Methionine adenosyltransferase α1 (MATα1, encoded by MAT1A) is responsible for hepatic biosynthesis of S-adenosyl methionine, the principal methyl donor. MATα1 also act as a transcriptional cofactor by interacting and influencing the activity of several transcription factors.

2024年10月22日 · Amidst ongoing debates on the role and mechanisms of methionine adenosyltransferase 1A (MAT1A) in cancer, our study sheds light on its significance in NSCLC. Leveraging TCGA database and...

The MAT1A gene encodes methionine adenosyltransferase, also known as S-adenosylmethionine (AdoMet) synthetase (EC 2.5.1.6), which catalyzes the formation of adenosylmethionine from methionine and ATP. Adenosylmethionine is an important methyl donor in …

2024年6月17日 · Clinical resource with information about MAT1A, Hepatic methionine adenosyltransferase deficiency, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.