2022年9月22日 · These m1A-modified early tRNAs enhance translation efficiency, enabling rapid and necessary synthesis of MYC and of a specific group of key functional proteins.

tRNA位58的m1A对tRNA结构、稳定性和翻译启动至关重要；这一位点m1A缺失可能促进tRNA衍生小RNA（tDRs）产生，增强核糖体组装并引起恶性表型。

2022年11月7日 · Among these modifications, N1 -methyladenosine (m 1 A), which is typically found at position 58 in cytoplasmic tRNA and is catalyzed by the TRMT6/61 A complex to enhance translation...

2025年1月28日，来自上海交通大学医学院&重庆医科大学李华兵研究员团队在Journal of Experimental Medicine杂志在线发表了题为tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells的研究论文，该研究首次发现TRMT61A介导的tRNA m1A修饰通过调控胆固 ...

2025年1月28日 · Mechanistically, tRNA m1A promotes antitumor immunity in CD8+ T cells by enhancing the translation of ATP citrate lyase, a key enzyme for cholesterol biosynthesis. Cholesterol supplementation rescues the impaired tumor-killing function and proliferation of TRMT61A-deficient CD8+ T cells.

2022年9月25日 · 除了tRNA丰度之外，tRNA上的化学修饰可以通过稳定tRNA结构，帮助tRNA进行codon识别等途径影响翻译过程。 其中，m 1 A是tRNA上丰度最高最保守的一种修饰，由 TRMT6/TRMT61A 复合物进行修饰，tRNA-m 1 A修饰可以增强翻译起始和延伸 [2]。

2022年12月22日 · In a recent paper published in Nature Immunology, Liu et al. reported that the m1A modification of transfer RNA can promote CD4+ T cell proliferation by enhancing the translation efficiency of a...

2017年2月21日 · The methylation on the N1 atom of adenosine to form 1-methyladenosine (m1A) has been identified at nucleotide position 9, 14, 22, 57, and 58 in different tRNAs. In some cases, these modifications have been shown to increase tRNA structural stability and …

2022年10月10日 · 9月22日，上海交通大学医学院上海市免疫学研究所李华兵研究员及合作团队在 Nature Immunology 上发表了题为“tRNA-m 1 A modification promotes T cell expansion via efficient MYC protein synthesis”的研究论文，该研究揭示了m 1 A修饰催化酶tRNA...

These m 1 A-modified early tRNAs enhance translation efficiency, enabling rapid and necessary synthesis of MYC and of a specific group of key functional proteins. The MYC protein then guides the exit of naive T cells from a quiescent state into a proliferative state and promotes rapid T cell expansion after activation.