The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which causes hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection.

Macrophage colony-stimulating factor (M-CSF) is a survival, growth, differentiation and activating factor for macrophages and their progenitor cells 1, 2. M-CSF is a complex cytokine, which can be produced as integral cell surface or secreted protein variants 3–6.

Macrophage colony-stimulating factor (M-CSF, also known as CSF-1) and granulocyte-macrophage colony-stimulating factor (GM-CSF) drive the monocyte/macrophage development, differentiation, and proliferation along with cytokines such as …

2020年11月9日 · Transcriptomic analysis of LPS-stimulated M-CSF–derived human macrophages after the addition of exogenous Ado and PGE 2 reveals a modest but similar change in gene expression.

M-CSF stimulates differentiation of progenitor cells to mature monocytes, and prolongs the survival of monocytes. It enhances cytotoxicity, superoxide production, phagocytosis, chemotaxis, and secondary cytokine production (G-CSF, IL-6, and IL-8) in monocytes and macrophages.

2020年8月17日 · Macrophage colony-stimulating factor (M-CSF) and IL-34 are ligands of CSF1R. CSF1R-mediated signaling is crucial for the survival, function, proliferation, and...

2013年7月17日 · Macrophage colony-stimulating factor (M-CSF) is a cytokine found in the brain whose receptor is expressed by microglia. Previous studies suggest a critical role for M-CSF in brain development and normal functioning as well as in several disease processes involving neuroinflammation.