
Innovative determination of Let-7a for lung cancer diagnosis …
In this study, we emphasize the importance of identifying Let-7a, a microRNA that is key in diagnosing and predicting lung cancer outcomes. Let-7a′s function as a biomarker is essential, as it affects tumor suppression and controls cell differentiation and growth.
MicroRNA profiling and identification of let-7a as a target to …
2019年7月3日 · Let-7a presented a stable and profound downregulated profile in all miRNA screening assays, indicating that let-7a may has a key role in chemotherapy induced ovarian damage.
The Roles of the Let-7 Family of MicroRNAs in the Regulation of …
Let-7e expression was found to be significantly reduced in cisplatin-resistant human epithelial ovarian cancer (EOC) cells, and the overexpression of let-7e by transfection of let-7e Agomir, a type of chemically modified double-strand miRNA mimics, reduces the expression of cisplatin-resistance-related proteins, including EZH2 and cyclin D1 ...
Overexpressed let-7a inhibits glioma cell malignancy by directly ...
Overexpression of let-7a reduced cell proliferation, induced G1/G0 phase arrest, increased apoptosis, and decreased the cell invasion and migration capacities of human glioblastoma cells. Furthermore, let-7a directly targeted K-ras to suppress glioma cells, independently of …
Reduced Let-7a Is Associated with Chemoresistance in Primary …
2015年7月28日 · In the present study, we found that upregulating the expression of let-7a can enhance apoptosis and reduce the survival of SK-3rd sphere cells exposed to epirubicin, and let-7a miRNA was subsequently found to enhance the chemosensitivity of SK-3rd sphere cells.
miRBase entry: oar-let-7a
Stem-loop oar-let-7a. Accession. MI0025243. Description. Ovis aries oar-let-7a precursor miRNA Literature search. 16 open access papers mention oar-let-7a (51 sentences) Sequence. 216705 reads, 74132 reads per million, 16 experiments Show Histogram ...
Let-7 as biomarker, prognostic indicator, and therapy for …
2019年8月28日 · In the study by Lu and colleagues, patients with ovarian cancer and high let-7a levels have better prognosis than those with low let-7a levels when treated with platinum-based therapy alone, but counterintuitively, high let-7a levels correlate with poor response when platinum is combined with paclitaxel.
A facile optical fiber-embedded microfluidic biochip for rapid and ...
2024年12月6日 · A novel hybridization chain reaction (HCR) powered optical fiber-embedded microfluidic biochip (HCR-FMB) has been constructed for ultrafast and sensitive detection of lethal-7a (let-7a) in serum.
miRBase entry: hsa-let-7a-3
MIRLET7A3 is a gene that belongs to the MIRLET7A gene family, which also includes MIRLET7A1 and MIRLET7A2 [PMC7459851]. It is located at 22q12.31 within the MIRLET7BHG gene [PMC6353855]. The hypermethylation of the MIRLET7A3 gene has been reported in various cancers, including acute myeloid leukemia, ovarian cancer, and breast cancer [PMC6353855].
Targeted delivery of let-7a microRNA encapsulated ephrin-A1
The effectiveness of targeted delivery of let-7a miR encapsulated ephrin-A1 conjugated LNP (miR-ephrin-A1-LNP) was determined on MPM and NSCLC tumor growth in vitro. miR-ephrin-A1-LNP significantly increased the delivery of let-7a miR in lung cancer cells when compared with free let-7a miR.
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