2022年12月19日 · Research has shown that esketamine can significantly reduce depression symptoms — relief that can last weeks after treatment ends. Though they’re far from perfect treatments, ketamine and esketamine mark a breakthrough, as they’re the only fast-acting antidepressants available.

2024年2月15日 · Ketamine has been used for decades as an anesthetic, and in 2019 an inhaled version of it was approved by the FDA for treatment-resistant depression. But it is generally prescribed only when other treatments have not been effective.

2025年1月31日 · Is ketamine a treatment for depression? What are the risks? Learn about the uses, benefits, and side effects of ketamine.

2019年4月30日 · Ketamine is a fast-acting antidepressant that relieves depressive symptoms in hours instead of the weeks or longer that previous drugs required. In addition to being a major advance in treatment, ketamine provides an opportunity for researchers to investigate the short- and long-term biological changes underlying its effects on depression.

In 14 publications, ketamine provided a rapid antidepressant effect with a maximum efficacy reached at 24 hrs. Its effect lasted for 1–2 weeks after infusion, but a longer-term effect is little reported. Ketamine does not seem to improve depressive symptoms at the end of electroconvulsive sessions.

2024年3月18日 · When at least two trials of a standard anti-depression medication fail to alleviate symptoms, ketamine treatment may be an option. When someone has depression, there are changes in the brain’s circuitry, including how neurons communicate with one another.

Intranasal esketamine has received regulatory approvals for the treatment of depression. Recently a large trial of repeated dose racemic ketamine also demonstrated efficacy in severe depression. However, uncertainties remain regarding comparative efficacy, dosage, and …

On March 5, 2019, the Food and Drug Administration (FDA) approved the first new medication for major depression in decades. The drug is a nasal spray called esketamine, derived from ketamine—an anesthetic that has made waves for its surprising antidepressant effect.

2022年11月1日 · Ketamine offers a new, fast-acting approach to relieving treatment-resistant depression. Learn the research-backed benefits and how to try it.

2023年5月31日 · In a clinical trial of 403 patients, Massachusetts General Brigham investigators found that 55 percent of those who received ketamine treatment experienced a sustained improvement in depressive symptoms without major side effects.