2024年9月12日 · The Janus kinase 2 (JAK2) gene directs cells to make the JAK2 protein, which stimulates cell growth and division. Learn what can cause a JAK2 gene mutation and associated conditions.

Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family ( IL-3R , IL-5R and GM-CSF-R ), the gp130 receptor family (e.g., IL-6R ), and the ...

2023年6月9日 · The JAK2 gene is a protein-coding gene of the Janus kinase family. It initiates several cellular signaling processes, including cell division, immunity, and tumor formation.

2024年12月25日 · JAK2 (Janus Kinase 2) is a Protein Coding gene. Diseases associated with JAK2 include Polycythemia Vera and Thrombocythemia 3. Among its related pathways are Signaling downstream of RAS mutants and Prolactin Signaling.

JAK2 mutations can act as central drivers of myeloproliferative neoplasia, a pre-leukemic and age-related malignancy. Likewise, hyperactive JAK-signaling is a hallmark of immune diseases and critically influences inflammation, coagulation and thrombosis.

The JAK2 gene provides instructions for making a protein that promotes the growth and division (proliferation) of cells. This protein is part of a signaling pathway called the JAK/STAT pathway, which transmits chemical signals from outside the cell to the cell's nucleus.

2025年3月8日 · Fatty Acid Binding Protein-4 Silencing Inhibits Ferroptosis to Alleviate Lipopolysaccharide-induced Injury of Renal Tubular Epithelial Cells by Blocking Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling.

JAK2 is a member of the Janus kinase (JAKs) family of non-receptor protein tyrosine kinases, which includes JAK1–3 and TYK2.

These results suggest a novel negative regulation of estrogen receptor alpha activity and protein by JAK2 in breast cancer cells and indicate a potential new cross-talk; Janus kinase 2 46/1 haplotype influences morphological distribution, increasing the predisposition towards an acute myelomonocytoid form.

2025年1月18日 · Mutations in this gene are associated with numerous inflammatory diseases and malignancies. This gene is a downstream target of the pleiotropic cytokine IL6 that is produced by B cells, T cells, dendritic cells and macrophages to produce an immune response or inflammation.