2024年12月25日 · ITGB4 (Integrin Subunit Beta 4) is a Protein Coding gene. Diseases associated with ITGB4 include Epidermolysis Bullosa, Junctional 5B, With Pyloric Atresia and …

Integrin, beta 4 (ITGB4) also known as CD104 (C luster of D ifferentiation 104), is a human gene. [5] Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently …

2020年2月15日 · We developed two immunologic strategies to target ITGB4: ITGB4 protein-pulsed dendritic cells (ITGB4-DC) for vaccination and adoptive transfer of anti-CD3/anti-ITGB4 …

ITGB4 was transcriptionally activated by TFAP2A, and could promote LUAD progression and inhibit CD4 + /CD8 + T-cell infiltrations by activating the NF-κB signaling pathway. ITGB4 may …

The ITGB4 gene provides instructions for making one part (the β4 subunit) of a protein known as an integrin. Learn about this gene and related health conditions.

2017年1月13日 · Our results indicated that ITGB4 induces HCC cell growth and invasiveness and promotes EMT via a mechanism involving the transcription factor Slug. ITGB4 promoted tumor …

ITGB4 is an effective diagnostic serum biomarker and a potential therapeutic target for CRC. Keywords: colorectal cancer, CyTOF, diagnosis biomarker, ITGB4, Single‐cell level.

2024年8月6日 · Integrin β4 (ITGB4) is a transmembrane protein that functions as a mechanosensor, mediating the bidirectional exchange of information between the intracellular …

2025年2月9日 · Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a …

Itgb4 protein remains expressed in the early stages of peripheral regeneration and subsequent myelination. integrin beta4 is implicated in and associated with p53 in autophagy of lung …

ITGB4-overexpressing CAF-conditioned medium promoted the proliferation, epithelial-to-mesenchymal transition, and invasion of breast cancer cells. In a co-transplant mouse model, …

2024年1月3日 · The ITGB4 (Integrin subunit beta 4) gene encodes a receptor for laminins and its upregulation in tumor tissues is associated with poor prognosis. However, its role in glioma is …

2025年2月9日 · Title: Identification of ITGB4 as a novel tumor promoting gene in lung adenocarcinoma (LUAD). Integrin beta4 induced epithelial-to-mesenchymal transition involves …

Integrin beta4 (ITGB4) is a transmembrane receptor that plays a key role in tumorigenesis and tumor development. However, there are no pan-cancer analyses of ITGB4. This study …

2024年8月7日 · Integrin β4 (ITGB4) is a transmembrane protein that functions as a mechanosensor, mediating the bidirectional exchange of information between the intracellular …

2019年9月18日 · ITGB4-overexpressing CAF-conditioned medium promoted the proliferation, epithelial-to-mesenchymal transition, and invasion of breast cancer cells. In a co-transplant …

When evaluating the association of ITGB4 with clinical features and MSI status in colon cancer, we found that high ITGB4 expression was associated with elder onset age, proximal tumor …

Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the …

ITGB4 expression can effectively predict the outcomes of patients with LUAD who are receiving anti-PD-1 therapy. ITGB4 knockdown inhibited the invasion, migration of H1975-BrM4 brain …

2023年10月3日 · Integrin β4 (ITGB4) is a major component of hemidesmosomes and a receptor molecule of laminin. Studies have shown that laminin-5 interacts with ITGB4 to activate RAC1 …