2016年9月19日 · Interleukin-33 (IL-33), which was identified as a member of the IL-1 family approximately 10 years ago 1, is now recognized to have a key role in innate and adaptive immunity, contributing to...

Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic inflammation, viral infection, and cancer.

2024年12月25日 · IL33 (Interleukin 33) is a Protein Coding gene. Diseases associated with IL33 include Autoimmune Pancreatitis and Granulomatous Mastitis. Among its related pathways are IL-1 Family Signaling Pathways and Constitutive Signaling by Aberrant PI3K in Cancer. Gene Ontology (GO) annotations related to this gene include cytokine activity.

Interleukin-33 (IL-33) is a tissue-derived nuclear cytokine from the IL-1 family abundantly expressed in endothelial cells, epithelial cells and fibroblast-like cells, both during homeostasis and inflammation.

Interleukin (IL)-33 is a key cytokine involved in type 2 immunity and allergic airway diseases. Abundantly expressed in lung epithelial cells, IL-33 plays critical roles in both innate and adaptive immune responses in mucosal organs.

2025年1月15日 · Here we show that interleukin-33 (IL-33), the alarmin released by inflamed tissues 2, induces TLSs. In mice, Il33 deficiency severely attenuates inflammation- and LTβR-activation-induced...

IL-33 is a newly characterized cytokine that amplifies both innate and adaptive immune responses. In this review, we discuss the role of IL-33 and its receptor ST2 in the pathogenesis of pulmonary inflammatory diseases. The IL-33/ST2 pathway is a potential therapeutic target in the treatment of lung diseases.

IL-33 plays important roles in type-2 innate immunity via activation of allergic inflammation-related eosinophils, basophils, mast cells, macrophages, and group 2 innate lymphoid cells (ILC2s) through its receptor ST2.

IL-33/ST2 signalling is involved in T-cell mediated immune responses, but more recently, an unanticipated role in cardiovascular disease has been demonstrated.

In this Review, we highlight the molecular and cellular characteristics of IL-33, together with its major role in health and disease and the potential therapeutic implications of these findings in humans.