Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. [ 3 ] [ 4 ] Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: after removal of the signal peptide sequence, the mature protein contains 133 amino acids in its ...

2024年6月12日 · IL-3 plays an important role in bones by directly targeting both osteoblasts and osteoclasts. IL-3 promotes the differentiation of human mesenchymal stem cells into osteoblasts and stimulates the formation and the survival of mononuclear osteoclasts .

2022年8月22日 · Interleukin-3 (IL-3) T cells and stem cells make IL-3. It functions as a multilineage colony-stimulating factor. Interleukin-4 (IL-4) CD4+T cells (Th2) synthesize IL-4, and it acts on both B and T cells. It is a B-cell growth factor …

Interleukin-3 (IL-3) is a cytokine that binds to a receptor composed of IL-3Rα and βc subunits, stimulating the growth of various progenitor cells and promoting the survival of macrophages, mast cells, and megakaryocytes.

Interleukin (IL)-3 is a multipotent hematopoietic growth factor produced by activated T cells, monocytes/macrophages and stroma cells. The human IL-3 gene is located on chromosome 5 near segment 5q31. The high-affinity receptor for human IL …

2024年12月25日 · antibodies-online: Show 180 available IL-3 Antibodies ranked by validation data; Compare Top IL-3 Antibodies

Interleukin (IL)-3 has long been known for its hematopoietic properties. However, recent evidence has expanded our understanding of IL-3 function by identifying IL-3 as a critical orchestrator of inflammation in a wide array of diseases. Depending ...

IL-3 transcriptionally regulates surface levels of Fcepsilon RI in human primary basophils. results indicated that the IL-3 rs40401 polymorphism is associated with increased risk of abortion of IVF patients; IL-3 also induces a shift towards secretion of proinflammatory cytokines.

The combination of IL-3 and GM-CSF was more efficient than G-CSF for supporting platelet recovery but was of similar benefit for the reconstitution of myelopoiesis. Following chemotherapy, IL-3 was found to attenuate neutropenia and/or thrombocytopenia in some but not all …

IL-3 is the most important growth and activating factor for human and mouse basophils, primary effector cells of allergic disorders. IL-3-activated basophils and mast cells are also involved in different chronic inflammatory disorders, infections, and several types of cancer.