Interleukin 13 (IL-13) is a cytokine that is responsible for promoting Th2 responses in humans and is released by T cells, mast cells, and eosinophils. It is typically associated with allergic inflammation, including asthma, but it also plays a role in fibrosis pathogenesis.

IL-13 is a cytokine that is produced by different T-cell subsets and dendritic cells. IL-13 shares many biologic activities with IL-4. This is due to the fact that IL-13– and IL-4–receptor complexes share the IL-4–receptor α-chain, which is important for signal transduction. T cells do not express functional IL-13 receptors.

IL-13 was first recognized for its effects on B cells and monocytes, where it upregulated class II expression, promoted IgE class switching and inhibited inflammatory cytokine production. It was also thought to be functionally redundant with IL-4.

IL-13 down-regulates PGE2 both directly and indirectly through effects on PGES and COX-2. IL-13 also induces 15-LO that is correlated with asthma severity. IL-13 induction of 15-LO stimulates formation of 15-HETE and a metabolite of this enhances MUC5AC expression in …

This review provides an update on the role of IL-13 in AD and discusses the different strategies aimed at interfering with its biologic activity as well as their potential in a precision medicine approach in the management of AD.

2. What We Know about IL-13 Comes from Studies of Its Biology in the Immune System. The cytokines Interleukin 13 (IL-13) and interleukin-4 (IL-4) are two secreted proteins recognized for their role in promoting T-helper type 2 (Th2) lymphocyte-mediated allergic inflammation and atopy in the periphery [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17].

Interleukin 13 (IL-13) is an immunoregulatory cytokine predominantly secreted by activated Th2 cells. IL-13 appears to be necessary in the effector phase of inflammation and has been shown to be involved in abnormal fibrosis [46].

2025年2月8日 · IL-13 can act on macrophages both before and after HIV-1 infection to interfere with virus replication by blocking the completion of reverse transcription, decreasing virus production, and reducing the infectivity of the progeny virions

2015年4月2日 · Interleukin-13 (IL-13) as a pleiotropic cytokine acts through the IL-13Ra1/IL-4Ra complex to induce activation responses which contribute to the inflammatory diseases. Genetic polymorphisms in IL-13 and its receptor components have been proved to be associated with higher disease prevalence rates.

IL-13 is a critical mediator of allergic inflammation. Although it shares many functional properties with IL-4, it has been shown to have distinct functions. Furthermore, IL-13 is more important than IL-4 in the development of airway hyperreactivity and mucus production.