IgG4-related disease (IgG4-RD), formerly known as IgG4-related systemic disease, is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4 -secreting plasma cells, various degrees of fibrosis (scarring) and a usually prompt response to oral steroids.

The treatment and prognosis of IgG4-RD is presented here. The pathogenesis, clinical manifestations, diagnosis, and differential diagnosis of IgG4-RD are presented in detail separately, as is the treatment of type 1 AIP and IgG4-related sclerosing cholangitis.

2024年9月10日 · Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that is capable of affecting multiple organs [1-3]. Organs affected by IgG4-RD share pathologic, serologic, and clinical features.

IgG4-related disease is an immune-mediated condition that can affect multiple organ systems. Common features include IgG4-related autoimmune pancreatitis, swelling of or within an organ system (an inflammatory pseudotumor), salivary gland disease (which can lead to enlargement of the salivary glands), swollen lymph nodes (lymphadenopathy), skin ...

2023年8月8日 · IgG4-related disease (IgG4-RD) is known as an IgG4-related systemic disease, hyper-IgG4 disease, IgG4-related autoimmune disease, IgG4-associated disease, IgG4-related sclerosing disease, and IgG4-syndrome.

Immunoglobulin G4-related disease (IgG4-RD) is a chronic immune-mediated fibroinflammatory disorder that often manifests with tumor-like masses and/or painless enlargement of multiple organs. Serum IgG4 level is often but not always elevated. Symptoms depend on which organs are affected. Diagnosis generally requires biopsy.

Immunoglobulin G4-related disease (IgG4-RD) is a chronic fibroinflammatory disorder that was identified in the 21st century. It is recognized as a systemic, immune-mediated condition, and …

2023年4月24日 · IgG4 is the least abundant subclass of IgG in human serum and has unique functional features. IgG4 is largely unable to activate antibody-dependent immune effector responses and, furthermore,...

This article will discuss IgG4 structure and function, the unique phenomenon of half-antibody exchange, and the implications of IgG4 biology for its proposed role in immunologic diseases.

IgG4 is the least common of the 4 subclasses of IgG. It has various normal functions in the body, but in IgG4-related disease, immune cells that produce IgG4, along with other related cells, accumulate abnormally in certain organs and damage them.