ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly ...

2024年12月25日 · ICAM1 (Intercellular Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with ICAM1 include Malaria and Cerebral Malaria. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Cytokine Signaling in Immune system.

2023年8月1日 · ICAM-1, an immunoglobulin (Ig)-like cell adhesion molecule, is expressed by two cell types: leukocytes and endothelial cells. ICAM-1 expression is mainly controlled by transcription. ICAM-1 plays a vital role in inflammation and …

Intercellular adhesion molecule-1 (ICAM-1) plays an important role in leukocyte trafficking, immunological synapse formation and, numerous cellular immune responses.

2024年11月1日 · Intercellular adhesion molecule-1 (ICAM-1) is a versatile molecule that plays a critical role in various physiological and pathological processes, particularly in tumor development where its impact is bidirectional.

2024年9月15日 · Intercellular adhesion molecule 1 (ICAM-1/CD54), a transmembrane glycoprotein, has been considered as one of the most important adhesion molecules during leukocyte recruitment. It is encoded by the ICAM1 gene and plays a central role in inflammation.

2014年5月15日 · ICAM-1 is an iconic marker of inflammation in EAE and multiple sclerosis, with elevated expression at lesion sites on endothelial cells and on infiltrating and resident CNS cells (7, 57, 58).

2021年12月1日 · Intracellular adhesion molecule 1 (ICAM-1) is one of the most extensively studied inducible cell adhesion molecule which is responsible for several immune functions. The molecule is constitutively expressed over the cell surface and is regulated up / down in response to inflammatory mediators.

2023年8月1日 · Intercellular adhesion molecule 1 (ICAM-1) and Vascular cell adhesion molecule 1 (VCAM-1) belong to the immunoglobulin superfamily of cell adhesion molecules (CAM) with a crucial role in mediating the strong adherence of leukocytes to endothelial cells in numerous acute as well as chronic diseases.

In their paper, Sumagin et al. have examined the role of ICAM-1 and the possible role of a leukocyte-endothelium interaction in the regulation of vascular permeability. During inflammation development, two major events occur.