ACO1, or IRP1, is a bifunctional protein that functions as an iron-responsive element (IRE)-binding protein involved in the control of iron metabolism by binding mRNA to repress translation or degradation. It functions also as the cytoplasmic isoform of aconitase.

During iron scarcity or oxidative stress, IRP1 binds to mRNA stem-loop structures called iron responsive elements (IREs) to modulate the translation of iron metabolism genes. In iron-rich conditions, IRP1 binds an iron-sulfur cluster to function as a cytosolic aconitase.

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in …

2006年7月18日 · Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post-transcriptionally regulate expression of iron metabolism genes to...

2011年11月24日 · Iron regulatory proteins (IRPs) 1 and 2 are RNA-binding proteins that control cellular iron metabolism by binding to conserved RNA motifs called iron-responsive elements (IREs). The currently known IRP-binding mRNAs encode proteins involved in iron uptake, storage, and release as well as heme synthesis.

IRP1 is a cytosolic post-transcriptional regulator of cellular iron metabolism [1, 2]. Under iron deficiency, it exhibits RNA-binding activity, which results in the stabilization of transferrin receptor 1 (TfR1) mRNA and the translational arrest of the mRNAs encoding ferritin and ferroportin.

Iron regulatory protein (IRP)1 and 2 play important roles in maintaining iron homeostasis, but their functions in ferroptosis have not been investigated. The present study reported that the expression of IRP1 and IRP2 was increased by the ferroptosis inducers erastin and RSL3 in melanoma cells.

2006年2月2日 · Iron-regulatory protein 1 (IRP1) is an iron-regulated RNA-binding protein that controls cellular iron metabolism. IRPs bind to iron-responsive elements (IRE) in mRNAs, thereby controlling mRNA fate (Eisenstein, 2000; Hentze et al, 2004).

The activities of IRP1 and IRP2 are regulated by distinct posttranslational mechanisms in response to cellular iron levels. Thus, in iron-replete cells, IRP1 assembles a cubane iron-sulfur cluster, which prevents IRE binding, while IRP2 undergoes proteasomal degradation.

Iron regulatory proteins (IRP) are sequence-specific RNA-binding proteins that mediate iron-responsive gene regulation in animals. IRP1 is also the cytosolic isoform of aconitase (c-aconitase). This latter activity could complement a mitochondrial aconitase mutation (aco1) in S accharomyces cerevisiae to restore glutamate prototrophy.

Cellular iron homeostasis is regulated by post-transcriptional feedback mechanisms, which control the expression of proteins involved in iron uptake, release and storage. Two cytoplasmic proteins with mRNA-binding properties, iron regulatory proteins 1 …

2022年10月5日 · Iron availability in mammalian cells is controlled by iron-regulatory protein 1 (IRP1) and IRP2. We report that global disruption of both IRP1 and IRP2 in adult mice impairs neutrophil development and differentiation in the bone marrow, yielding immature neutrophils with abnormally high glycolytic and autophagic activity, resulting in neutropenia.

Iron-regulatory proteins (IRPs) 1 and 2 are key controllers of vertebrate iron metabolism and post-transcriptionally regulate expression of the major iron homeostasis genes.

2013年8月29日 · IRP1 controls HIF2α mRNA translation in vivo and thereby acts as an upstream regulator of Epo expression. IRP1 deficiency leads to age-dependent erythropoietic abnormalities and misregulation of body iron metabolism via the HIF2α/Epo pathway. Hypoxia inducible factor 2α (HIF2α) transcriptionally activates several genes in response to hypoxia.

2024年3月27日 · In this review, we summarize the main virulence factors investigated in K. pneumoniae from different human infections. We also cover the specific identification genes and their prevalence in K. pneumoniae, especially in hypervirulent strains.

2024年11月11日 · Gene therapy involves the introduction of genetic material into cells to replace or repair defective genes, while gene editing allows for precise modifications to the genome. These technologies can potentially cure diseases that were previously untreatable, offering hope to individuals and families affected by genetic conditions.

IRP1 promotes iron uptake, reduces iron export, and activates ferritinophagy, increasing redox-active iron levels and ROS derived from Fenton chemistry. Oxidative damage of membrane phospholipids triggers membrane rupture, the final step of ferroptosis.

Iron Regulatory Protein 1 (IRP1) is a cytosolic protein that plays a crucial role in maintaining cellular iron homeostasis by regulating the expression of genes involved in iron metabolism, responding to cellular iron deficiency by binding to iron-responsive elements (IREs) in …

2024年2月14日 · K. pneumoniae strains that produce carbapenemase / ESBL are known to possess antimicrobial resistance and virulence genes.

掲載種別： 研究論文（学術雑誌） 出版者・発行元： Springer Science and Business Media LLC Abstract Cellular communication network factor 2 (CCN2) molecules promote endochondral ossification and articular cartilage regeneration, and circular RNAs (circRNAs), which arise from various genes and regulate gene expression by adsorbing miRNAs, are known to be …