2024年12月25日 · IRF8 (Interferon Regulatory Factor 8) is a Protein Coding gene. Diseases associated with IRF8 include Immunodeficiency 32A and Immunodeficiency 32B. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Cytokine Signaling in Immune system.

2011年7月14日 · We detected two distinct disease-causing mutations affecting interferon regulatory factor 8 (IRF8). Both K108E and T80A mutations impair IRF8 transcriptional activity by disrupting the...

2020年3月30日 · IRF8 deficiency in humans causes a severe primary immunodeficiency presenting as susceptibility to infections, complete or severe depletion of blood dendritic cells (DC) subsets, depletion of CD14+ and CD16+ monocytes and reduced numbers and impaired activity of NK cells.

IRF8 deficiency in humans causes a severe primary immunodeficiency presenting as susceptibility to infections, complete or severe depletion of blood dendritic cells (DC) subsets, depletion of CD14 + and CD16 + monocytes and reduced numbers and impaired activity of …

2022年8月24日 · Interferon regulatory factor 8 (IRF8) is a transcription factor of the IRF protein family. IRF8 was originally identified as an essentialfactor for myeloid cell lineage commitment and differentiation.

IRF8 is a Reliable Monoblast Marker for Acute Monocytic Leukemias. PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages. Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis.

2022年8月24日 · Interferon regulatory factor 8 (IRF8) is a transcription factor of the IRF protein family. IRF8 was originally identified as an essentialfactor for myeloid cell lineage commitment and differentiation. Deletion of Irf8 leads to massive accumulation of CD11b + Gr1 + immature …

2006年9月1日 · IRF8, another immune-cell-specific member of the IRF family, is also involved in the TLR9–MyD88 pathway . IRF8 increases signalling by interacting with, and activating, TRAF6 (Ref. 98).

IRF8 is a negative regulator of MDSCs and involved in neoplasia deterioration. Using or developing specific targeted therapies for IRF8 may contribute to the treatment and prognosis of immune disorders. Shengbo Zhang, ... Stephen L. Nutt. IRF8 is …

2024年12月10日 · Title: IRF8 Regulates Intrinsic Ferroptosis through Repressing p53 Expression to Maintain Tumor Cell Sensitivity to Cytotoxic T Lymphocytes. Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer.