2011年4月14日 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial regulator of...

2024年12月25日 · This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue.

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. [5]

This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue.

干扰素调节因子（irf）7最初被认为是产生ifn-i并调节先天免疫反应的主要转录因子，随后的研究表明irf7在多种生物过程中发挥多方面和多功能的功能。 在这篇综述中，我们全面概述了 IRF7 在免疫和自身免疫中的作用的当前知识。

2023年8月10日 · In this review, we provide a comprehensive overview on the current knowledge of the role of IRF7 in immunity and autoimmunity. We focus on the latest regulatory mechanisms of IRF7 in IFN-I, including signaling pathways, transcription, translation, and post-translational levels, the dimerization and nuclear translocation, and the role of IRF7 in ...

2023年8月9日 · MicroRNAs regulate IRF7 expression by modulating mRNA stability. miR-223 and miR-155-5p enhance IRF7 expression by targeting FOXO3 (37, 38), miR-127 promotes IRF7 expression by inhibiting the signal-dependent turnover of the Bcl6 coregulator , miR-144 negatively regulates IRF7 activity by suppressing the TRAF6-IRF7 signaling axis , and miR29a ...

Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs) family, is located downstream of the pattern recognition receptors (PRRs)-mediated signaling pathway and is essential for the production of type I interferon ...

干扰素调节因子 7 (irf7) 最初是在爱泼斯坦-巴尔病毒 (ebv) 感染的背景下发现的，后来成为 i 型干扰素 (ifn) 对抗病原体感染的关键调节因子，其通过触发信号级联反应激活 irf7识别病原体核酸的病原体识别受体（prr）。

2005年4月7日 · Using mice deficient in the Irf7 gene (Irf7-/- mice), we show that the transcription factor IRF-7 is essential for the induction of IFN-alpha/beta genes via the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway.