Interferon regulatory factor 5 (IRF5) belongs to a family of transcription factors, originally implicated in antiviral responses and interferon production. However, studies conducted in different laboratories over the last decade have placed IRF5 as a central regulator of the inflammatory response.

2024年12月25日 · IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Inflammatory Bowel Disease 14 and Systemic Lupus Erythematosus 10. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll-like receptor signaling pathway.

Here, we review the advances made by various studies in targeting multiple steps of signalling leading to IRF5 activation with their therapeutic potential, and the possible complications of such strategies are discussed.

Previously, our laboratory identified the transcription factor interferon regulatory factor 5 (IRF5) as the master regulator of the M1 macrophage polarisation. IRF5 was found to be highly expressed in human M1 compared to M2 macrophages.

The transcription factor interferon regulatory factor 5 (IRF5) plays essential roles in pathogen-induced immunity downstream of Toll-, nucleotide-binding oligomerization domain–, and retinoic acid–...

Interferon regulatory factor 5 (IRF5; encoded by IRF5), a pivotal transcription factor in the type I IFN pathway, regulates the expression of IFN-dependent genes, inflammatory cytokines and genes involved in apoptosis.

IRF5) is a DNA binding domain deletion mutant of wild type IRF5 (variant 3, GenBank TM accession number AY504946) and is missing the first N-terminal 137 amino acids.

The protein produced from the IRF5 gene, called interferon regulatory factor 5 (IRF5), acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. Learn about this gene and related health conditions.

2006年9月1日 · IRF7 is essential for the robust type I IFN gene induction that is elicited by ligation of TLR7 or TLR9, whereas IRF5 is required for the induction of pro-inflammatory cytokine genes. By...

2024年1月1日 · Interferon Regulatory Factor 5 (IRF5) is among nine mammalian members of the interferon regulatory factor (IRF) family of transcription factors that mediate interferon (IFN) signaling in both arms of the immune system – innate and adaptive.