HMG-CoA reductase - Wikipedia
HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, official symbol HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent, …
The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases
Three-dimensional structures of the catalytic domain of HMG-CoA reductases from humans and from the bacterium Pseudomonas mevalonii, in conjunction with site-directed mutagenesis …
The Increasingly Complex Mechanism of HMG-CoA Reductase
The seven decades of research on the mechanism of HMG-CoA Reductase (HMGR) provided a detailed reaction pathway for what is one of the most biomedically important and …
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase [ (human)]
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from …
Regulation of HMG-CoA reductase in mammals and yeast - PMC
HMG-CoA reductase (HMGR), a highly conserved, membrane-bound enzyme, catalyzes a rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of …
Hydroxymethylglutaryl-CoA reductase, a key enzyme in ... - PubMed
Hydroxymethylglutaryl-CoA reductase (HMGR) regulates the synthesis of mevalonic acid (MVA), the precursor of the myriad of isoprenoid compounds functional in plant cells, with phytosterols …
Identification of 3-hydroxy-3-methylglutaryl monoacyl-coenzyme …
2025年3月5日 · The main chemical constituents found in sandalwood essential oils are sesquiterpenes. 3-Hydroxy-3-methylglutaryl monoacyl-coenzyme A reductase (HMGR) is one …
The increasingly complex mechanism of HMG-CoA reductase
2013年11月19日 · HMG-CoA reductase (HMGR) is the target of statins, cholesterol-lowering drugs prescribed to millions of patients worldwide. More recent research indicates that HMGR …
Human 3-Hydroxy-3-methylglutaryl-CoA Reductase
Human 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is a tightly regulated tetrameric enzyme. HMGR catalyzes an essential four-electron reduction of 3-hydroxy-3-methylglutaryl …
The 3-hydroxy-3-methylglutaryl-coenzyme A reductase 5 gene ... - PubMed
3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) is the first rate-limiting enzyme regulating the synthesis of terpenoids upstream of the mevalonate (MVA) pathway.
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