2024年12月25日 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Pheochromocytoma and Retinal Ischemia. Among its related pathways are Signaling by PTK6 and Autodegradation of the E3 ubiquitin ligase COP1.

Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. This review summarizes the role and regulation of the HIF-1 α in cancer and recent therapeutic approaches targeting this important pathway. 1. The role of HIF-1 α pathway in cellular adaptation to hypoxic stress.

2019年6月20日 · HIF-1α (HIF1A) is known to be associated with the upregulation of glycolytic genes such as phosphoglycerate kinase (PGK) and lactate dehydrogenase A (LDHA), both of which function to...

2008年2月15日 · In keeping with the complexity of the hypoxic response, three principal isoforms of HIF- α exist (HIF-1 α, HIF-2 α and HIF-3 α). All are encoded by distinct gene loci and further diversity is...

Recently, it has been identified that hypoxia-inducible factor-1 alpha (HIF-1α) is a major transcriptional regulatory factor that responds to hypoxic environments and modulates the expression of many genes in the organism and is closely associated with the biological behavior of malignant tumors. 1,2 Importantly, HIF-1α is commonly highly expres...

HIF1A promotes miR-210/miR-424 transcription to modulate the angiogenesis in HUVECs and HDMECs via sFLT1 under hypoxic stress. HIF-1alpha and Nrf2 regulates hypoxia induced overexpression of DDAH1 through promoter activation in prostate cancer.

HIF-1α can function as a multifunctional supplement for hypoxia since it regulates hypoxic genes and the environment, including angiogenesis, erythropoiesis, and glycolysis [3].

2004年2月29日 · Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a constitutively expressed HIF-1beta subunit and one of three subunits (HIF-1alpha, HIF-2alpha or HIF-3alpha).

2025年3月21日 · Multiomics identifies HIF1A as a key mediator of H3K27ac modifications that regulate gene expression and enhance myometrial cell contractions under hypoxia during labour, providing potential ...

Hypoxia-inducible factor 1α (HIF-1α) is a subunit of the HIF-1 transcription factor which is encoded by the HIF1A gene. This transcription factor is the main modulator of the cell response to hypoxia. Hypoxia-induced up-regulation of HIF-1α is involved in the pathogenesis of cancer.