Hepatoma-derived growth factor (HDGF) was identified in research seeking to find a novel growth factor for hepatoma cells. Subsequently, four HDGF-related proteins were identified, and these proteins are considered to be members of a new gene family.

Inhere we discuss the MET molecular structure and the hepatocyte growth factor driven physiological signaling which coordinates epithelial proliferation, motility and morphogenesis. Keywords: signaling pathways, tyrosine kinase receptor, protein–protein interaction, SH2 domain, post translational modification, signal transduction. 1.

Hepatocyte growth factor (HGF) is a peptide-containing multifunctional cytokine that acts on various epithelial cells to regulate cell growth, movement and morphogenesis, and tissue regeneration of injured organs. HGF is sequestered by heparin-like protein in its inactive form and is widespread in the extracellular matrix of most tissues.

Plasma from patients with fulminant hepatic failure contains a factor that stimulates the growth of adult rat hepatocytes in primary culture. Gohda et al. (1988) purified HGF from a patient's plasma and showed that it has multiple forms with molecular mass between 76 and 92 kD.

2002年4月15日 · Hepatocyte growth factor (HGF), a heparin-binding factor, was originally described as a potent mitogen for the growth of hepatocytes in vitro and was subsequently purified from rat platelets, 1 plasma of a patient with fulminant hepatic failure, 2 and normal human plasma. 3 HGF has mitogenic, motogenic, and morphogenic effects on various epithel...

Hepatocyte growth factor (HGF) is produced by various types of cells. It has a wide distribution of tissues and can participate in the maintenance and renewal of vital organs such as liver, lung, and kidney, then promote the regeneration of these organs.

Hepatocyte growth factor (HGF), also knownasscatter factor (SF),is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on …

2024年12月25日 · HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and a variety of other cells, including endothelial and epithelial cells, melanocytes, and keratinocytes. It also mediates epithelial morphogenesis.

2011年5月8日 · We performed a translational medicine protocol with recombinant human HGF (rh-HGF), including a phase I/II study of patients with fulminant hepatitis (FH) or late-onset hepatic failure (LOHF), in order to examine the safety, pharmacokinetics, and clinical efficacy of …