Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein.

2024年12月25日 · HBEGF (Heparin Binding EGF Like Growth Factor) is a Protein Coding gene. Diseases associated with HBEGF include Diphtheria and Perinatal Necrotizing Enterocolitis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Signaling by ERBB2 KD Mutants.

2024年2月26日 · Using proteomic analyses of cerebrospinal fluid specimens from patients with MS in combination with experimental studies, we here identify Heparin-binding EGF-like growth factor (HB-EGF) as a...

Gene expression analysis suggests a role of basic helix-loop-helix protein 40 (BHLHE40) in transcriptional activation of heparin-binding epidermal growth factor (HBEGF). Screening for HB-EGF SNPs/genotypes and plasma levels may be useful as a risk factor for necrotizing enterocolitis in the future.

The subset we refer to as HBEGF + inflammatory macrophages is enriched in RA tissues and is shaped by resident fibroblasts and the cytokine tumor necrosis factor (TNF).

Heparin-binding EGF-like growth factor (HB-EGF) is an EGF family member that interacts with epidermal growth factor receptor (EGFR) and ERBB4.

Heparin-binding epidermal growth factor–like growth factor (HB-EGF) is a member of the EGF family. It contains an EGF-like domain as well as a heparin-binding domain that allows for interactions with heparin and cell-surface heparan sulfate.

Background and Aims: Heparin-binding EGF-like growth factor (HB-EGF) is a representative EGF family member that interacts with EGFR under diverse stress environment. Previously, we reported that the HB-EGF-targeting using antisense oligonucleotide (ASO) effectively suppressed an aortic aneurysm in the vessel wall and circulatory lipid levels. In this study, we further …

2018年1月1日 · HB-EGF is a heparin-binding member of the EGFR ligands that was initially identified in the conditioned medium of human macrophage-like cells (Higashiyama et al. 1991). HB-EGF directly binds to and activates EGFR and ErbB4. The ErbB family of receptor tyrosine kinases (RTKs) consists of four receptors: EGFR/ErbB1, ErbB2, ErbB3, and ErbB4.

2018年11月19日 · The authors identify HB-EGF, an EGFR ligand, as a key driver of EMT and a potential new therapeutic target for the amelioration of EMT and airway remodelling. There are also wider...