Trifunctional enzyme subunit beta, mitochondrial (TP-beta) also known as 3-ketoacyl-CoA thiolase, acetyl-CoA acyltransferase, or beta-ketothiolase is an enzyme that in humans is encoded by the HADHB gene.

2024年12月25日 · HADHB (Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Beta) is a Protein Coding gene. Diseases associated with HADHB include Mitochondrial Trifunctional Protein Deficiency 2 and Mitochondrial Trifunctional Protein Deficiency .

HADHB - hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Gene

线粒体三功能酶β亚基（英語： Trifunctional enzyme subunit beta, mitochondrial ，TP-beta）也被称为3-ketoacyl-CoA thiolase、acetyl-CoA acyltransferase或beta-ketothiolase 是一种由人类基因 HADHB 所编码的酶 [5] 。 HADHB是线粒体三功能蛋白的一个亚基，并具有 硫解酶 （ 英语 …

HADHB forms a heterodimer with HADHA and functions as an FAO enzyme together with HADHA; however, the relevance of its expression in malignant lymphoma is unknown. In this study, we investigated the roles and antitumour effects of …

2022年4月1日 · In vitro analysis demonstrated that HADHB knockdown suppressed cell proliferation in LCL-K and MD901 cells (p<0.05). Additionally, treatment with the FAO inhibitor, ranolazine, increased cell death in control cells compared with that in HADHB knockdown LCL-K and MD901 cells (p<0.01).

hadhb 基因突变导致的线粒体三功能蛋白缺乏，可分为三种表型: 01 新生儿发病（重度/心脏表型）：新生儿在出生后几天内出现低血糖、肝肿大、脑病，并且经常出现心肌病

2023年11月29日 · hadha或hadhb致病性变异杂合的孕妇（包括疑似携带者）应监测 hellp 综合征和妊娠期急性脂肪肝。 在妊娠前两个三个月期间，每次产前检查时都应进行肝功能检测，而在妊娠晚期，则应进行更频繁的检查，此时 HELLP 综合征和妊娠期急性脂肪肝的风险最大。

HADHB, a fatty acid beta-oxidation enzyme, is a potential prognostic predictor in malignant lymphoma. MTP deficiency caused by HADHB mutations: Pathophysiology and clinical manifestations. Targeting viperin to the mitochondrion inhibits the thiolase activity of the trifunctional enzyme complex.

线粒体三功能酶β亚基（ 英语： Trifunctional enzyme subunit beta, mitochondrial ，TP-beta）也被称为3-ketoacyl-CoA thiolase、acetyl-CoA acyltransferase或beta-ketothiolase 是一种由人类基因 HADHB 所编码的酶 。 HADHB是线粒体三功能蛋白的一个亚基，并具有硫解酶活性。