Glyoxalase I is an attractive target for the development of drugs to treat infections by some parasitic protozoa, and cancer. Several inhibitors of glyoxalase I have been identified, such as S- (N-hydroxy-N-methylcarbamoyl)glutathione.

2024年12月25日 · GLO1 (Glyoxalase I) is a Protein Coding gene. Diseases associated with GLO1 include Pulmonary Tuberculosis and Hyperglycemia. Among its related pathways are Regulation of pyruvate metabolism and Respiratory electron transport. Gene Ontology (GO) annotations related to this gene include lactoylglutathione lyase activity.

Glyoxalase I (GLO1), glyoxalase II (GLO2), and reduced glutathione (GSH). In bacteria, there is an additional enzyme that functions if there is no GSH, it is called the third glyoxalase protein, glyoxalase 3 (GLO3).

2020年11月1日 · GLO1 is a key rate-limiting enzyme in the glyoxalase system and it is linked to diabetes, cardiovascular disease, neurodegenerative disorders, and multidrug resistance in cancer chemotherapy. GLO1 regulators are developed to sustain healthy aging, to treat GLO1-related diseases and complications.

2012年11月19日 · Glyoxalase 1 (GLO1) is a ubiquitous cellular enzyme that participates in the detoxification of methylglyoxal (MG), a cytotoxic byproduct of glycolysis that induces protein modification (advanced glycation end-products, AGEs), oxidative stress, and apoptosis. The concentration of MG is elevated under high-glucose conditions, such as diabetes.

In this review, we discuss the role of Glo1 in the malignant progression of cancer and its possible use as a promising therapeutic target for tumor therapy. We also summarize therapeutic outcomes of Glo1 inhibitors as prospective treatments for the prevention of cancer. Keywords: cancer, cancer stem cell, glyoxalase 1, methylglyoxal.

Glo1 is involved in the Min-U-Sil 5 crystalline silica-induced BEAS-2B cell mitochondrial apoptotic pathway. Two classes of the metalloenzyme GlxI exist and vary in their metal dependencies; GLO1 activity affects the overall burden of carotid artery atherosclerosis.

Real time quantitative PCR (qPCR) analysis of all amplicon 6p21.2 genes in 618 human cancer cell lines identified GLO1, encoding glyoxalase 1, to be the most frequently amplified gene [twofold or greater amplification in 8.4% (49/536) of cancers]. Also the association between amplification and overexpression was greatest for GLO1.

Small molecule inducers of Glo1, Glo1 inducers, have been developed to alleviate dicarbonyl stress as a prospective treatment for the prevention and early-stage reversal of type 2 diabetes and prevention of vascular complications of diabetes.

2021年5月8日 · Here, we found that disruption of GLO1, the gene encoding a major catabolic enzyme scavenging the carbonyl group, increases vulnerability to external carbonyl stress, leading to abnormal...