2024年12月25日 · GLIS2 (GLIS Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with GLIS2 include Nephronophthisis 7 and Acute Megakaryoblastic Leukemia In Children Without Down Syndrome. Among its related pathways is Ciliopathies.

GLIS family zinc finger 2 also known as GLIS2 is a human gene. [1][2] The protein encoded by this gene is a Kruppel-like transcription factor which functions depending on the gene and promoter context as an activator or repressor of gene transcription. [2] . GLIS2 plays a role in kidney development and neurogenesis. [2]

2024年5月1日 · Inactivation of Glis2 suppresses polycystic kidney disease in mouse models of ADPKD, and pharmacological targeting of Glis2 with antisense oligonucleotides slows disease progression. Glis2...

2020年6月1日 · GLIS2 deficiency caused the elevation of H3K27ac and p53 binding on the PUMA enhancer, and promoted PUMA expression. It increased the rate of apoptosis, but not cell cycle. Moreover, GLIS2...

Glis2 is one of three Glis transcription factor family members whose zinc fingers share high homology with the Gli family. Like the Gli proteins, Glis2 is detected in the primary cilium, but it is not required for proper cilia formation.

2025年2月8日 · Study identified Glis2 as a transcription factor mutated in Nephronophthisis and demonstrate its essential role for the maintenance of renal tissue architecture through prevention of apoptosis and fibrosis. Glis2 functions as a negative …

该基因是 Gli 类似锌指蛋白家族的成员，编码具有五个 C2H2 型锌指结构域的核转录因子。 由该基因编码的蛋白质在神经管和周围神经系统中以低水平广泛表达，并可能促进神经元分化。 它在肾脏中大量表达，可能在肾脏形态发生的调节中起作用。 p120 调节该蛋白的表达水平并诱导该蛋白的 C 末端锌指结构域的切割。 该蛋白还促进 p120 的核转位。 该基因的突变会导致肾病 (NPHP) ，这是一种常染色体隐性遗传性肾病，其特征是肾小管基底膜破裂、间质性淋巴组织细胞浸润和肾 …

2020年6月1日 · GLIS2 deficiency caused the elevation of H3K27ac and p53 binding on the PUMA enhancer, and promoted PUMA expression. It increased the rate of apoptosis, but not cell cycle. Moreover, GLIS2 represses H3K27ac level on enhancers, regulates the gene expression related with focal adhesion and promotes cell migration, through inhibiting p300.

In this study, we describe the characterization of a gene encoding a novel Krüppel-like protein, named Glis2. Glis2 encodes a relatively proline-rich, basic 55.8-kDa protein. Its five tandem Cys2-His2 zinc finger motifs exhibit the highest homology to those of members of the Gli and Zic subfamilies of Krüppel-like proteins.

2002年3月22日 · In this study, we describe the characterization of a gene encoding a novel Krüppel-like protein, named Glis2. Glis2 encodes a relatively proline-rich, basic 55.8-kDa protein. Its five tandem Cys 2 -His 2 zinc finger motifs exhibit the highest homology to those of members of the Gli and Zic subfamilies of Krüppel-like proteins.