GAB2 Gene - GeneCards | GAB2 Protein | GAB2 Antibody
2024年12月25日 · GAB2 (GRB2 Associated Binding Protein 2) is a Protein Coding gene. Diseases associated with GAB2 include Noonan Syndrome-Like Disorder With Loose Anagen …
GAB2 - Wikipedia
GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. [5] [6] [7] [8] GAB2 is a docking protein with a conserved, folded PH …
蛋白包括Gab1、Gab2和Gab3。 该家族蛋白可通过介导膜受体与信号转导蛋白间的耦联及各信号分子间的相互作用参与信号 转导，其主要是通过激活SHP2/RAS/ERK和PI3K/AKT两条经典的 …
Structure and function of Gab2 and its role in cancer (Review)
Gab2, a key member of the Gab family of proteins, is involved in the amplification and integration of signal transduction, evoked by a variety of extracellular stimuli, including growth factors, …
GAB2 GRB2 associated binding protein 2 [ (human)] - National …
GAB2 is the limiting component of the GAB2-SHP2 complex, signaling Erk MAP kinase activation and terminal differentiation of K562 CML cells. The docking protein Gab2 is overexpressed …
Gab2 growth factor receptor bound protein 2-associated protein …
2025年2月8日 · Gab2 is an important player in neural differentiation, partly by acting downstream of bFGF to mediate survival through phosphoinositide 3 kinase-AKT; Gab2 via Shp-2 is critical …
GAB2--a scaffolding protein in cancer - PubMed
GAB2 is essential for two major signal transduction pathways in cancer, the PI3-K-AKT and extracellular signal-regulated kinase (ERK) signaling pathways, and thus regulates a number …
Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in …
2021年4月8日 · Gab2 (Grb2-associated binder2) silencing suppresses thrombin-induced signaling and inflammation in endothelial cells. A, Human umbilical vein endothelial cells (HUVECs) …
Gab2 is a novel prognostic factor for colorectal cancer patients
2015年3月1日 · Gab2 (Grb2-associated binder 2), a member of the DOS/Gab family of scaffolding adapters, serves as a critical signal amplifier downstream of various growth factor receptors. …
Gab2 signaling in chronic myeloid leukemia cells confers ... - Nature
2012年8月3日 · We show for the first time that Gab2 signaling protects CML cells from various Bcr-Abl inhibitors (imatinib, nilotinib, dasatinib and GNF-2), whereas Gab2 knockdown or …