Soluble fms-like tyrosine kinase-1 (sFlt-1 or sVEGFR-1) is a tyrosine kinase protein with antiangiogenic properties.

2001年2月1日 · Flt-1, also known as vascular endothelial growth factor receptor 1 (VEGFR-1), is a high-affinity tyrosine kinase receptor for VEGF and is expressed almost exclusively on …

Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene. [5] FLT1 is a member of VEGF receptor gene family. It encodes a receptor tyrosine …

2024年12月25日 · Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the …

2001年2月1日 · Flt-1, also known as vascular endothelial growth factor receptor 1 (VEGFR-1), is a high-affinity tyrosine kinase receptor for VEGF and is expressed almost exclusively on …

2025年3月8日 · Title: FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer. Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1 …

An important feature of VEGFR-1 is that, unlike other VEGFR genes, it expresses two types of mRNA, one for a full-length receptor and another for a soluble short protein known as soluble …

sFlt-1 (sVEGFR-1) is an antiangiogenic factor expressed as an alternatively spliced variant of VEGFR-1 that lacks both the transmembrane and cytoplasmic domains. sFlt-1 binds VEGF …

VEGFR2 (also known as FLK1) is the primary receptor that binds VEGFA, and therefore controls angiogenesis in both healthy and diseased tissues. By contrast, VEGFR1 (also known as …

2019年3月13日 · Soluble Flt-1 (sFlt-1) is a known mediator of vascular events that cause preeclampsia. A recent study showed that suppressing the synthesis of sFlt-1 in mouse and …