F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene. [5][6][7] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box.

2024年12月25日 · FBXW7 (F-Box And WD Repeat Domain Containing 7) is a Protein Coding gene. Diseases associated with FBXW7 include Developmental Delay, Hypotonia, And Impaired Language and Colorectal Cancer. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Class I MHC mediated antigen processing and …

2018年8月7日 · FBXW7 is a critical tumor suppressor and one of the most commonly deregulated ubiquitin-proteasome system proteins in human cancer. FBXW7 controls proteasome-mediated degradation of oncoproteins such as cyclin E, c-Myc, Mcl-1, mTOR, Jun, Notch and AURKA.

FBXW7 (F-Box and WD Repeat Domain Containing 7) (also referred to as FBW7 or hCDC4) is a component of the Skp1-Cdc53 / Cullin-F-box-protein complex (SCF/β-TrCP). As a member of the F-box protein family, FBXW7 serves a role in ...

2022年4月19日 · In this review, we mainly elaborate on seven hallmarks of cancer influenced by FBXW7, including maintaining growth signals, resisting cell death, inducing angiogenesis, activating invasion and metastasis, reprogramming energy metabolism, avoiding immune destruction, and genome instability and mutation.

The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in the degradation of many oncoproteins via the ubiquitin-proteasome system …

2023年9月2日 · Low levels of FBXW7 cause abnormal stability of pertinent substrates, mutations and/or deletions in the FBXW7 gene have been reported to correlate with breast cancer malignant progression and chemoresistance.

5 天之前 · F-box and WD repeat domain-containing 7 (FBXW7) is a tumor suppressor that targets various oncoproteins for degradation, but its role in modulating cancer-associated fibroblasts (CAFs) in the tumor microenvironment remains elusive. Here, we report that FBXW7 expression is gradually downregulated in …

Recently, F-box and WD Repeat Domain-containing-7 (FBXW7), a recognized tumor suppressor, has been found to be highly associated with tumor therapy resistance. This review provides a comprehensive summary of the underlying mechanisms through which FBXW7 facilitates the development of drug resistance in cancer.

2025年2月9日 · FBXW7 polymorphism asserts susceptibility to colorectal cancer. Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/beta-catenin pathway inhibition. FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells.