FKBP1A (also known as FKBP12) is notable in humans for binding the immunosuppressant molecule tacrolimus (originally designated FK506), which is used in treating patients after …

It is also commonly referred to as FKBP-12 or FKBP12 and is a member of a family of FK506-binding proteins .

In this review, we have summarized the information from a study on FKBP12 (FK506 binding protein 12 kDa) with a view to understand its drug-free, physiological roles in transcription of …

2001年2月20日 · FKBP12, the 12-kDa FK506-binding protein, is a ubiquitous abundant protein that acts as a receptor for the immunosuppressant drug FK506, binds tightly to intracellular …

FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs …

The primary target of FK506 in cells is FKBP12; therefore, we tested whether SLF and rapamycin, other FKBP12 inhibitors, can recapitulate the activity of FK506. Both chemicals suppressed …

The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling …

We describe the development of an FKBP12-recruiting CIP-DNA en- coded library for discovery of CIPs aimed at modulating protein-protein interactions. From this library, we

2011年4月4日 · We generated FKBP12 overexpressing transgenic (αMyHC-FKBP12) mice and cardiomyocyte-restricted FKBP12 conditional knockout (FKBP12 f/f /αMyHC-Cre) mice, and …

Know comprehensive FKBP12 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.