2024年12月24日 · ECE1 (Endothelin Converting Enzyme 1) is a Protein Coding gene. Diseases associated with ECE1 include Hirschsprung Disease, Cardiac Defects, And Autonomic Dysfunction and Hypertension, Essential. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Endosomal endothelin-converting enzyme-1 is a regulator of beta-arrestin-dependent ERK signaling By degrading endocytosed SP, ECE-1 promotes the recycling and re-sensitization of NK(1) receptors in endothelial cells, and thereby induces …

We report the identification of ECE-1, a novel membrane-bound neutral metalloprotease that is expressed abundantly in endothelial cells in vivo and is structurally related to neutral endopeptidase 24.11 and Kell blood group protein.

2023年10月28日 · Endothelin converting enzyme 1 (ECE1) is a membrane-bound metalloprotease involved in endothelin-1 (ET-1) processing and regulates vasoconstriction. However, very few studies have reported the involvement of ECE1 in regulating tumor cell proliferation, and the mechanism remains poorly understood.

2006年6月8日 · HGNC Approved Gene Symbol: ECE1. Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1; 131240), -2 (EDN2; 131241), and -3 (EDN3; 131242) to biologically active peptides.

Title: Endothelin-converting enzyme-1 regulates glucagon-like peptide-1 receptor signalling and resensitisation. ECE-1 and ECE-2 levels were significantly reduced in post-mortem brains from dementia with Lewy body patients.

ECE1 is a prognostic marker in Lung adenocarcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.

Endothelin‐1 is a mitogenic peptide that activates several proliferation, survival, and invasiveness pathways. The effects of endothelin‐1 rely on its activation by endothelin‐converting enzyme‐1 (ECE1), which is expressed as four isoforms with different cytoplasmic N termini.

2014年1月31日 · Endothelin-converting enzyme-1 (ECE-1) is the enzyme predominantly responsible for producing active endothelin-1 (ET-1), a mitogenic peptide implicated in the aetiology of a number of diseases, including cancer.

These observations identify enzymatic processing of C. albicans Ece1p by kexin-like proteinases as crucial steps required for candidalysin production and fungal pathogenicity. KEYWORDS: Candida albicans, candidalysin, fungal infection, kexin, mucosal immunity.