2013年8月1日 · Mechanism of Action. Digoxin inhibits sodium-potassium ATPase, an enzyme that regulates the quantity of sodium and potassium inside cells. Inhibition of the enzyme leads to an increase in the intracellular concentration of sodium and thus (by stimulation of sodium-calcium exchange) an increase in the intracellular concentration of calcium.

2023年8月15日 · What is digoxin? Digoxin is derived from the leaves of a digitalis plant. Digoxin helps make the heart beat stronger and with a more regular rhythm. Digoxin is used to treat heart failure. Digoxin is also used to treat atrial fibrillation, a heart rhythm disorder of the atria (the upper chambers of the heart that allow blood to flow into the ...

2024年12月15日 · 12.1 Mechanism of Action. All of digoxin’s actions are mediated through its effects on Na-K ATPase. This enzyme, the “sodium pump,” is responsible for maintaining the intracellular milieu throughout the body by moving sodium ions out of and potassium ions into cells. By inhibiting Na-K ATPase, digoxin •

2010年10月20日 · 1 Answer - Posted in: digoxin - Answer: Positive Inotrope - increases force of contraction. Negative Chronotrope -...

2025年1月23日 · 12.1 Mechanism of Action. All of digoxin’s actions are mediated through its effects on Na-K ATPase. This enzyme, the “sodium pump,” is responsible for maintaining the intracellular milieu throughout the body by moving sodium ions out of and potassium ions into cells. By inhibiting Na-K ATPase, digoxin •

2024年11月15日 · Digoxin is a substrate of the P-glycoprotein (P-gp) transporter) and may interact with other drugs that induce or inhibit P-gp, such as amiodarone, protease inhibitors, or rifampicin. Use digoxin cautiously with other medicines that can depress sinus or AV nodal function, inhibit renal function, or that alter gastrointestinal transit time.

Digoxin immune Fab is a specific antidote that binds to digoxin (preventing and reversing pharmacologic and toxic effects and enhancing elimination) and can be used in the treatment of potentially life-threatening acute or chronic digoxin toxicity. Massive digoxin overdosage may cause hyperkalemia, which can be refractory to conventional therapy.

2023年8月21日 · (Note interactions with digoxin under PRECAUTIONS) Hypotension: Occasionally, the pharmacologic action of verapamil may produce a decrease in blood pressure below normal levels, which may result in dizziness or symptomatic hypotension. The incidence of hypotension observed in 4,954 patients enrolled in clinical trials was 2.5%.

2025年2月11日 · 12.1 Mechanism of Action. Piroxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of piroxicam, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Piroxicam is a potent inhibitor of prostaglandin (PG) synthesis in vitro.

2024年3月25日 · Digibind - Clinical Pharmacology. After intravenous injection of Digoxin Immune Fab (Ovine) in the baboon, digoxin-specific Fab fragments are excreted in the urine with a biological half-life of about 9 to 13 hours. 1 In humans with normal renal function, the half-life appears to be 15 to 20 hours. 2 Experimental studies in animals indicate that these antibody …