RIG-I is encoded by the DDX58 gene in humans. [9] [15] RIG-I is a helical ATP-dependent DExD/H box RNA helicase with a repressor domain (RD) on the C-terminus that binds to the …

2024年12月25日 · RIGI (RNA Sensor RIG-I) is a Protein Coding gene. Diseases associated with RIGI include Singleton-Merten Syndrome 2 and Singleton-Merten Dysplasia. Among its related …

Among the misregulated mRNAs was Ddx58, which was upregulated over 2-fold in mutant mice. Immunohistochemical analysis showed abnormally elevated Ddx58 expression in cytoplasm of …

Chromosome 9: 32,455,300-32,526,322 reverse strand. This gene has 5 transcripts (splice variants), 3 paralogues and is associated with 2 phenotypes. Sorry, the page request …

2024年3月13日 · In this study, we investigated the role of DDX58 (DExD/H-box helicase 58), also known as RIG-I, in TNBC chemoresistance. Methods: The relationship between DDX58 …

2022年12月18日 · RIG-I or DExD/H-box helicase 58 (DDX58) is a protein that recognizes viral double-stranded RNA and produces type I interferon, an antiviral and innate immune response …

2024年8月30日 · The best studied is DDX58, where K63-linked polyubiquitination induces oligomerization and antiviral gene expression . Additional PTMs such as phosphorylation …

MDA-5 (also known as FIH1 or Helicard) and RIG-I (aka Ddx58) recognize a complementary set of cytosolic viral dsRNA [3]. MDA-5 recognizes long dsRNA and accordingly senses the single …

2025年2月22日 · Furthermore, loss of YTHDF2 in bladder cancer (BLCA) cells activated an innate immune response, enhancing CD8 + T cell infiltration into the TME. Mechanistically, YTHDF2 …

Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and …