2024年12月24日 · DCLK1 (Doublecortin Like Kinase 1) is a Protein Coding gene. Diseases associated with DCLK1 include Band Heterotopia and Zellweger Syndrome. Among its related pathways are B Cell Receptor Signaling Pathway and Development EGFR signaling pathway.

The present review discusses the different roles of DCLK1 and its interactions with other proteins that are homologically similar to DCLK1 to develop a novel therapeutic strategy to target cancer cells more accurately.

2023年3月13日 · Doublecortin-like kinase 1 (DCLK1), a microtubule-associated protein kinase, is involved in neurogenesis, and its levels are elevated in various human cancers. Recent studies suggest that...

Originally designated Doublecortin and CaM kinase-like 1 protein (Dcamkl1) or KIAA0369, Dclk1 was first described as a marker for radial glia cells in the context of microtubule polymerization and neuronal migration, possibly contributing to early neurogenesis.

Despite recent advancements, the 5 year survival of head and neck squamous cell carcinoma (HNSCC) hovers at 60%. DCLK1 has been shown to regulate epithelial-to-mesenchymal transition as well as serving as a cancer stem cell marker in colon, pancreatic and renal cancer.

DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis. Targeting DCLK1 overcomes 5-fluorouracil resistance in colorectal cancer through inhibiting CCAR1/beta-catenin pathway-mediated cancer stemness. DCLK1 might be a therapeutic target of osthole against cervical cancer.

2017年7月3日 · Originally designated Doublecortin and CaM kinase-like 1 protein (Dcamkl1) or KIAA0369, Dclk1 was first described as a marker for radial glia cells in the context of microtubule polymerization and neuronal migration, possibly contributing to early neurogenesis.

2017年2月1日 · Doublecortin-like kinase 1 (Dclk1), a kinase protein, is overexpressed in colorectal cancer and specifically marks tumor stem cells (TSCs) that self-renew and increased the tumor progeny in Apc Min/+ mice.

Doublecortin‑like kinase 1 (DCLK1) has been identified as a novel biomarker of cancer stem cells among several different cancer types, including colon, breast, pancreas, kidney, liver, stomach and esophageal cancers.

2021年6月17日 · DCLK1 exists in long and short isoforms (DCLK1-L and DCLK1-S) generated by two alternative promoter usage with important differences between the isoforms in both human and mouse tissues.