2024年12月24日 · DDIT3 (DNA Damage Inducible Transcript 3) is a Protein Coding gene. Diseases associated with DDIT3 include Myxoid Liposarcoma and Soft Tissue Sarcoma. Among its related pathways are Gene expression (Transcription) and Unfolded Protein Response (UPR).

DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. [5] [6] It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. [6]

dna 损伤诱导转录物 3： 该基因编码 ccaat/增强子结合蛋白 (c/ebp) 转录因子家族的成员。该蛋白质通过与其他 c/ebp 成员 (如 c/ebp 和 lap (肝激活蛋白) ) 形成异二聚体并阻止其 dna 结合活性，从而发挥显性失活抑制剂的作用。该蛋白质与脂肪生成和红细胞生成有关，被内质网应激激活，并促 …

2024年10月3日 · This study finds a new role of DDIT3 in promoting necroptosis independently of its known function as a transcription factor; DDIT3 directly binds to p38 and MK2 thereby blocking MK2 activation...

ddit3，即dna损伤诱导转录本3，别名chop、gadd153，是一种转录因子，对细胞应激反应尤其是内质网应激具有关键调控作用。 它通过与ATF4相互作用，促进自噬相关基因表达，并通过抑制mTOR信号通路激活细胞自噬。

2025年3月8日 · CEBPZ is a widely used alternative name for DNA damage inducible transcript 3 (DDIT3), which can be confused with the official symbol for CEBPZ (CCAAT enhancer binding protein zeta, GeneID: 10153). [12 Nov 2020]

2022年12月9日 · Overexpression of DDIT3 in human healthy HSCs induces an MDS-like transcriptional state, and dyserythropoiesis, an effect associated with a failure in the activation of transcriptional programs...

DDIT3, also known as GADD153 or CHOP, encodes a basic leucine zipper transcription factor of the dimer forming C/EBP family. DDIT3 is known as a key regulator of cellular stress response, but its target genes and functions are not well ...

DDIT3 is induced during glutamine deprivation to promote glycolysis and adenosine triphosphate production via suppression of the negative glycolytic regulator TIGAR. In concert, a proportion of the DDIT3 pool translocates to the mitochondria and suppresses oxidative phosphorylation through LONP1-mediated down-regulation of COQ9 and COX4.

2024年3月20日 · DNA damage-inducible transcript 3 (DDIT3) gene, mapped to the human chromosome 12q13.3, encodes a protein that belongs to the CCAAT/enhancer-binding protein family of transcription factors. DDIT3 is involved in the proliferative control that responds to endoplasmic reticulum stress in normal conditions, dimerising other transcription factors ...