CTGF, also known as CCN2 or connective tissue growth factor, [5] [6] is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein).

Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis.

Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple pathologies, such as tumor development and tissue fibrosis.

Connective tissue growth factor (CTGF) is a 38kDa, cysteine rich, extracellular matrix protein composed of four domains or modules. CTGF has been shown to regulate a diverse array of cellular functions and has been implicated in more complex ...

2012年6月6日 · CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and extracellular matrix deposition and remodeling, which together lead to tissue remodeling and fibrosis.

The overexpression of a matricellular protein, connective tissue growth factor (CTGF), is a hallmark of fibrosis in multiple tissues in the mediation of the pro-fibrotic effects of tumor growth factor-β (TGF-β) . CTGF is a primary mediator of TGF-β-induced pulmonary fibrosis.

2018年8月1日 · Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis.

Connective Tissue Growth Factor (CTGF) CTGF is considered to be profibrotic by a mechanism related to TGF-β. CTGF is a TGF-β target gene that is activated by Smad proteins after TGF-β binds to its receptors. Like TGF-β, CTGF stimulates …

Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis.

2002年7月22日 · Connective-tissue growth factor (CTGF) is a secreted protein implicated in multiple cellular events including angiogenesis, skeletogenesis and wound healing 1. It is a member of the CCN...