2019年12月4日 · Constrictive Pericarditis. Colchicine's primary role in acute inflammatory pericardial conditions is to decrease inflammation and improve symptoms and quality of life. Clinicians are also trying to avoid an evolution towards constrictive physiology that is often associated with debilitating right heart failure.

2020年1月7日 · Acute pericarditis should be treated with a nonsteroidal anti-inflammatory drug (NSAID), typically with a 2- to 4-week taper after the resolution of symptoms. In addition, a 3-month course of colchicine (with weight-adjusted dosing) is recommended to reduce the risk of recurrent pericarditis.

2020年8月13日 · The COPE (COlchicine for acute PEricarditis) prospective, randomized, open-label trial, which included patients with a first episode of acute pericarditis, showed that colchicine, in addition to conventional anti-inflammatory therapy, significantly reduced symptoms at 72 hours (11.7% vs. 36.7%; p=0.003). 1 In addition, the recurrences of ...

2022年12月5日 · Colchicine has been used effectively in SLE pericarditis as a steroid-sparing drug; prolonged treatment beyond 3 months may be necessary due to the elevated risk of recurrence in this population. 9 Steroids are used to treat other organ manifestations of SLE and can be used in SLE pericarditis but have significant short and long-term adverse ...

2011年1月1日 · Colchicine has been shown to be promising for the secondary prevention of recurrent pericarditis in the CORE (recurrent pericarditis) and COPE (acute pericarditis) open-label studies. The current trial sought to compare the safety and efficacy of colchicine compared with placebo, in addition to standard therapy, in patients with recurrent ...

2020年1月17日 · Colchicine, in combination with aspirin/nonsteroidal anti-inflammatory drugs (NSAIDs), is first-line pharmacotherapy for acute and recurrent idiopathic pericarditis. This combination reduces rate of recurrence within 18 months.

2022年6月6日 · Pericarditis can be safely and successfully treated during pregnancy and breastfeeding with a targeted approach. Appropriate care of women pre-conception, antepartum and postpartum is essential in optimizing maternal and fetal outcomes.

2023年4月24日 · The authors found that prophylactic colchicine after AF ablation did not affect the incidence of post-ablation pericarditis and was associated with a significantly increased incidence of gastrointestinal side effects.

2024年4月15日 · Colchicine 0.5 mg daily is FDA-approved for secondary prevention in patients with coronary artery disease (CAD). These recommendations are rooted in the findings of the LoDoCo2 and COLCOT trials that showed a 31% drop in cardiovascular events in patients with clinically stable atherosclerosis.

2014年1月1日 · Colchicine has been shown to be promising for the secondary prevention of recurrent pericarditis in the CORE (recurrent pericarditis), COPE (acute pericarditis) open-label studies, and the CORP (first recurrent pericarditis) trials.