Molecular mechanisms and cellular functions of cGAS–STING ... - Nature
2020年5月18日 · Cyclic GMP–AMP synthase (cGAS) consists of a two-lobed catalytic domain and an extended amino-terminal (N-terminal) domain.
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
2021年4月30日 · cGAS (also known as C6orf150, or male abnormal 21 domain containing 1 (MAB21D1)) is located on chromosome 6q13 and encodes a protein with 522 amino acids in human. Mechanistically, cGAS...
Structural mechanism of cytosolic DNA sensing by cGAS
2013年5月30日 · Recognition of cytosolic DNA by the recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of cGAMP to activate the stimulator of interferon genes (STING). Here we...
The Mechanism of Double-stranded DNA Sensing through the cGAS …
Cyclic GMP-AMP synthase (cGAS) is a cytosolic dsDNA sensor mediating the innate immunity to microbial DNA. cGAS is activated by dsDNA and catalyzes the synthesis of a cyclic dinucleotide cGAMP with 2',5' and 3',5' phosphodiester linkages. cGAMP binds to the adaptor STING located on the endoplasmic reticulum membrane and mediates the recruitment ...
Structures and Mechanisms in the cGAS-STING Innate
2020年7月14日 · The enzymatic domain of cGAS belongs to the large family of nucleotidyltransferases (NTases), which are mostly known to catalyze the transfer of nucleoside monophosphate (NMP) from a nucleoside triphosphate (NTP) donor to diverse acceptors, including DNA, RNA, proteins, and small molecules.
cGAS in action: Expanding roles in immunity and inflammation
2019年3月8日 · Early structural and functional studies on cyclic guanosine monophosphate–adenosine monophosphate (GMP–AMP) synthase (cGAS) have established its capability to interact with dsDNA in a sequence-independent manner.
Current understanding of the cGAS-STING signaling pathway: …
Structurally, cGAS consists of an N-terminal positively charged domain responsible for cGAS dimer stabilization and a globular C-terminal catalytic domain consisting of a NTase core for enzymatic activity and Mab21 domain for DNA binding.
Structures and Mechanisms in the cGAS-STING Innate Immunity …
The cGAS-STING pathway mediates innate immune responses to pathogenic DNA from microbes or damaged cells. In this review, Zhang et al. focus on recent biochemical and structural studies of key proteins in the cGAS-STING pathway that provide …
The N-Terminal Domain of cGAS Determines Preferential ... - PubMed
2019年2月26日 · The non-enzymatic N-terminal domain of cGAS determines nucleo-cytoplasmic localization, enrichment on centromeres, and activation of nuclear-localized cGAS. These results reveal a preferential functional association of nuclear cGAS with centromeres.
Human cGAS catalytic domain has an additional DNA-binding …
2019年6月11日 · We expand on an earlier ladder model of cGAS dimers bound to a pair of parallel-aligned DNAs to propose a multivalent interaction-mediated cluster model to account for DNA-mediated condensation involving both the N-terminal domain of …
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