2024年12月24日 · CD8A (CD8 Subunit Alpha) is a Protein Coding gene. Diseases associated with CD8A include Immunodeficiency 116 and Hemolytic Uremic Syndrome, Atypical 6. Among its related pathways are TCR Signaling (Qiagen) and Network map …

2025年2月8日 · Title: Joint effects of CD8A and ICOS in Long QT Syndrome (LQTS) and Beckwith-Wiedemann Syndrome (BWS). Induced CD8alpha identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation.

Gene ID: 925, updated on 8-Feb-2025. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system.

CD8A is a novel indicator for predicting the prognosis and immunotherapeutic response in BCa. A radiomics signature has the potential to preoperatively predict the expression of CD8A in BCa patients. Keywords: bladder cancer, CD8A, MRI, radiogenomics, immunotherapy, prognosis. 1. …

In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. ... show less

2024年9月17日 · Clinical resource with information about CD8A, Susceptibility to respiratory infections associated with CD8alpha chain mutation, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Cd8a and Cd8b1 coreceptor gene (Cd8) expression is tightly controlled during T-cell development by the activity of five Cd8 enhancers (E8I–E8V). Here we demonstrate a unique transcriptional program regulating CD8 expression during CD8 + effector T-cell differentiation.

1 天前 · Additionally, in our patient cohort, individuals with low VPS72 expression exhibited higher CD8A expression. Furthermore, we identified a co-expression subtype characterized by low VPS72 and high CD8A levels, which showed a more favorable disease-free survival outcome in HCC. The expression of VPS72 in tumors is associated with the tumor ...

2025年3月14日 · CD8 + T cells were isolated using the Miltenyi mouse CD8a + T cell isolation kit (catalog no. 130-104-075) according to the manufacturer’s instructions. Cells were resuspended in RPMI at a concentration of 1 × 10 6 cells/ml, and 100 μl per well was plated in a 96-well plate. Dynabeads with mouse T-activator CD3/CD28 (Gibco, catalog no ...

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex.