2013年2月20日 · In healthy individuals, CD19 + CD24 hi CD38 hi B cells suppress CD4 + CD25 − T cell proliferation as well as the release of interferon-γ and tumor necrosis factor–α by these cells; this suppression is partially mediated through the production of interleukin-10 (IL-10).

2010年1月29日 · After CD40 stimulation, CD19 (+)CD24 (hi)CD38 (hi) B cells suppressed the differentiation of T helper 1 cells, partially via the provision of interleukin-10 (IL-10), but not transforming growth factor-beta (TGF-beta), and their suppressive capacity was reversed by the addition of CD80 and CD86 mAbs.

Here, we describe the preliminary characterization of a proposed new population of memory B cells, defined as CD19 + CD38 − CD24 −, which we find at higher frequencies in the elderly but less so in CO than healthy age-matched random controls.

In the present study, CD19 +, CD24 +, and CD38 + were used as markers to characterize Breg cells from peripheral blood of periodontitis patients. We observed a significant increase in the peripheral Breg cells in the periodontitis group when compared to healthy controls.

In this study we aimed to determine the role of CD19 + CD24 hi CD38 hi cells and some other clinicopathological variables in increasing the proportion of Tregs in breast cancer patients. Methods: We selected 47 patients with invasive ductal breast carcinoma and 50 healthy controls and obtained their blood samples.

2013年2月20日 · In healthy individuals, CD19 (+)CD24 (hi)CD38 (hi) B cells suppress CD4 (+)CD25 (-) T cell proliferation as well as the release of interferon-γ and tumor necrosis factor-α by these cells; this suppression is partially mediated through the production of interleukin-10 (IL-10).

Here, we describe that CD19 + CD24 hi CD38 hi B cells isolated from human PB inhibited the differentiation of T helper 1 (Th1) cells in vitro. This suppressive effect was mediated by a combination of the release of IL-10 and by the engagement of CD80 and CD86.

2023年9月1日 · Here, we investigated the frequency and functional changes of circulating CD19 + CD24 hi CD38 hi B cells and evaluated the correlation of CD19 + CD24 hi CD38 hi B cells with clinical features and T helper cell subsets in IMN patients.

2020年5月5日 · We observed a numerical deficit of CD19 + CD24 hi CD38 hi B cells in CAD and decreased secretion of anti-inflammatory cytokines IL-10 and TGF-β by Bregs. CD19 + CD24 hi CD38 hi B cells deficient in CAD is negatively correlated with the severity of atherosclerosis.

2020年3月15日 · Since regulatory T (Tregs) and B (Bregs) cells modulate the progression of infectious diseases, this study aimed at examining how these cells are involved with the development of HCV infection. Methods: The frequencies of circulating Bregs and Tregs were characterized using flow cytometry.