2024年12月24日 · CCL3 (C-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CCL3 include Human Immunodeficiency Virus Type 1 and Aseptic Meningitis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

2006年5月19日 · Antibodies specific for CC-chemokine ligand 3 (CCL3) or CCL4 inhibited the accumulation of OT-I T cells in lymph nodes containing activated OT-II T cells. Both CD4 + T cells and DCs were...

Macrophage inflammatory protein-1 alpha (MIP-1α/CCL3) is a chemotactic chemokine secreted by macrophages. It performs various biological functions, such as recruiting inflammatory cells, wound healing, inhibition of stem cells, and maintaining ...

CCL3, also known as macrophage inflammatory protein 1α (MIP-1α), induces inflammatory cytokines to specific sites by binding to the CCR1/3/9 receptors (Li et al., 2020). CCL3 is mainly produced by mononuclear macrophages, lymphocytes, and neutrophils, but can also be produced by …

CCL3 or macrophage inflammatory protein-1α (MIP-1α), an important chemokine implicated in both immune surveillance and tolerance, has emerged as a prognostic biomarker in both solid and hematological malignancies.

CCL3 promotes VEGF-A expression and angiogenesis in human osteosarcoma cells by down-regulating miR-374b expression via JNK, ERK, and p38 signaling pathways. The residues on the N-loop and beta-sheets of MIP-1a are close to both CCR1 and CCR5, and those in the C-terminal helix region are close to CCR5.

In response to BCR activation, CLL cells secrete the chemokine CCL3, which fosters interactions between CLL cells and the leukemia microenvironment. CCL3 secretion correlates with expression of the 70-kDa ζ-associated protein (ZAP-70) and responsiveness of the CLL clone to BCR stimulation.

2025年2月23日 · Targeted liver delivery of rAAV-Ccl3 reprograms the immune microenvironment in HCC, promoting immune cell recruitment and tertiary lymphoid structure formation, thus suppressing tumor growth via immune engagement.

In this study, we examined how CCL3 in a murine colon tumor microenvironment, CT26, enhances antitumor immunity. We identified natural killer (NK) cells as a major lymphocyte subtype that is preferentially recruited to the CCL3-rich tumor site.

2020年4月1日 · For example, neutrophils isolated from septic mice express Ccr2 mRNA, are capable of CCL2 and CCL3 binding, and display CCL2/3-induced chemotaxis. 216 Consistently, blocking CCR2 resulted...