2024年12月24日 · CAMK2B (Calcium/Calmodulin Dependent Protein Kinase II Beta) is a Protein Coding gene. Diseases associated with CAMK2B include Intellectual Developmental Disorder, Autosomal Dominant 54 and Autosomal Dominant Non-Syndromic Intellectual Disability .

2025年1月4日 · Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain.

2025年2月8日 · CaMKII regulates KCNQ1 at S484 during sustained beta-AR stimulation to inhibit IKs. The ability of CaMKII to inhibit IKs may contribute to arrhythmogenicity during HF. The importance of CAMK2A and CAMK2B and their auto-phosphorylation in human brain function.

The CAMK2B gene encodes a subunit of calcium/calmodulin-dependent protein kinase II (CaM kinase II, CAMK2), a multifunctional serine/threonine kinase that has critical roles in synaptic plasticity, learning, and memory, including long-term potentiation.

2022年9月2日 · Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic plasticity, learning and memory. It is...

Herein, after highlighting the main structural and expression differences between the α and β isoforms, we will review the specific functions of CaMKIIβ, as described so far, in neuronal development and plasticity, as well as its potential implication in brain diseases.

2019年7月10日 · Ca 2+ /calmodulin-dependent protein kinase II (CAMK2) is a key player in synaptic plasticity and memory formation. Mutations in Camk2a or Camk2b cause intellectual disability in humans, and severe plasticity and learning deficits in mice, indicating unique functions for each isoform.

2021年6月1日 · CAMK2 is encoded by four distinct genes, known as CAMK2A, CAMK2B, CAMK2D and CAMK2G (Sloutsky et al., 2020; Tombes et al., 2003). Each CAMK2 subunit is composed of an N-terminal catalytic domain, a C-terminal hub domain and an autoregulatory domain in the middle.

2025年2月8日 · Enables calcium/calmodulin-dependent protein kinase activity. Involved in regulation of neuron migration. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; modulation of chemical synaptic transmission; and protein phosphorylation. Located in cytosol; postsynaptic density; and spindle midzone.

'Dominant mutations in CAMK2B, encoding a subunit of the calcium/calmodulin-dependent protein kinase II (CAMK2), a serine/threonine kinase playing a key role in synaptic plasticity, learning and memory, underlie a recently characterized neurodevelopmental disorder (MRD54) characterized by delayed ps …