It is a Ca 2+ ATPase that transfers Ca 2+ from the cytosol of the cell to the lumen of the SR at the expense of ATP hydrolysis during muscle relaxation. In the skeletal muscles the calcium pump in the sarcoplasmic reticulum membrane works in harmony with similar calcium pumps in …

Calcium is an ambivalent signal: it is essential for the correct functioning of cell life, but may also become dangerous to it. The plasma membrane Ca 2+ ATPase (PMCA) and the plasma membrane Na + /Ca 2+ exchanger (NCX) are the two mechanisms responsible for …

As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the sarcoplasmic reticulum (SR) following muscle contraction.

2023年7月25日 · A particularly important calcium channel is the sarcoplasmic reticulum calcium ATPase (SERCA) pump, which transports calcium from the cytoplasm to the sarcoplasmic reticulum and complements the actions of PMCA and …

In this review, we introduce the distinct subtypes of Ca 2+ -ATPases and their isoforms and splice variants, and provide an overview of their specific cellular roles as they relate to genetic disorders and cancer, with a particular emphasis on recent findings on the secretory pathway Ca 2+ -ATPases (SPCA).

Sarcoplasmic Endoreticulum Calcium ATPase (SERCA) is an enzyme that functions in coupling the energy from hydrolysis of ATP to the active transport of key ions across membranes. In muscle, SERCA is responsible for lowering intracellular calcium concentration to 10 −7 M and thus bringing about relaxation of a contractile event.

Calcium ATPases are pumps found in the membranes of various organelles and in the plasma membrane, which transport calcium against its concentration gradient from the cytosol into the lumen or the extracellular space [78,79] (Figure I). This process requires hydrolysis of ATP.

Cooperating with Na+/Ca2+ exchangers (NCXs) and Ca2+ buffering proteins, PMCAs play an essential role in maintaining the long-term cellular Ca2+ homeostasis.

The Calcium ATPase consists of 994 amino acids. The protein includes a head in the cytoplasmic region and a t ransmembrane region consisting of ten helices (M1 - M10). Four stalk leading from helices M2, M3, M4, and M5 connect the transmembrane section to the cytoplasmic headpiece.

The calcium pump (a.k.a. Ca 2+ -ATPase or SERCA) is a membrane transport protein ubiquitously found in the endoplasmic reticulum (ER) of all eukaryotic cells. As a calcium transporter, SERCA maintains the low cytosolic calcium level that enables a vast array of signaling pathways and physio …