Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein. It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system. This subfamily includes enzymes that catalyze metabolism of xenobiotics , including some proton pump inhibitors and antiepileptic drugs.

The CYP2C19 gene provides instructions for making an enzyme that is found primarily in liver cells in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport.

The CYP450 enzyme CYP2C19 is at least partly involved in the metabolism of many drugs, but inhibitors of CYP2C19 will tend to have the greatest effect on drugs for which CYP2C19 is the primary pathway (eg, those with an asterisk in Table 1).

CYP2C19 genotype-guided drug prescribing has been proven in several trials to increase pharmacological effectiveness and safety. For example, CYP2C19 PMs have been observed to have a greater risk of cardiovascular events in patients receiving antiplatelet treatment with clopidogrel following stent installation.

2023年9月1日 · Among the various enzymes responsible for drug metabolism, CYP2C19 stands out as a pivotal player. This article explores the significant role of CYP2C19 in the body, its involvement in metabolizing specific medications, and the impact of pharmacogenetics on individual drug responses. What does CYP2C19 do in the body?

2019年2月14日 · A genome-wide association study of a healthy Amish population found that the CYP2C19*2 allele was the primary genetic locus associated with diminished platelet inhibitory response to clopidogrel and that the CYP2C19*2 allele accounted for 12% of the interpatient variability in platelet response to clopidogrel. 19

The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both, efficacy and safety ...

2018年1月30日 · CYP2C19 is an enzyme involved in the hydroxylation of the S form of an anti-epileptic agent mephenytoin, and also in the metabolism of a series of proton pump inhibitors such as omeprazole. The PM for CYP2C19 is found in about 20% of Japanese and about 3% of Caucasians [14].

2024年12月24日 · CYP2C19 (Cytochrome P450 Family 2 Subfamily C Member 19) is a Protein Coding gene. Diseases associated with CYP2C19 include Drug Metabolism, Poor, Cyp2c19-Related and Major Depressive Disorder. Among its related pathways are Clomipramine Pathway, Pharmacokinetics and Metapathway biotransformation Phase I and II.

2016年10月3日 · Clinical resource with information about CYP2C19, A genome-wide association study of acenocoumarol maintenance dosage., Amitriptyline response, An atlas of genetic influences on human blood metabolites., Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy., Brivaracetam response ...