CTCF binds at chromatin domain boundaries, at enhancers and gene promoters, and inside gene bodies. It can attract many other transcription factors to chromatin, including tissue-specific transcriptional activators, repressors, cohesin and RNA polymerase II, and it …

2015年6月5日 · CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an...

2024年12月24日 · CTCF (CCCTC-Binding Factor) is a Protein Coding gene. Diseases associated with CTCF include Intellectual Developmental Disorder, Autosomal Dominant 21 and Ctcf-Related Disorder. Among its related pathways are RNA Polymerase I Promoter Opening and Nervous system development.

2014年3月11日 · CTCF-mediated chromatin loops regulate diverse nuclear processes, including V (D)J recombination, enhancer–promoter interactions, transcriptional pausing and alternative mRNA splicing. The...

Our study highlights the heterogeneity of CBSs, uncovers properties specific to architecturally important CBSs, and provides insights into the basic processes of genome organization and transcription regulation. CCCTC-binding factor (CTCF) is a DNA-binding protein with diverse roles in chromatin architecture and gene regulation.

2024年12月27日 · Topologically associating domains (TADs) are essential components of three-dimensional (3D) genome organization and significantly influence gene transcription regulation. However, accurately identifying TADs from sparse chromatin contact maps and exploring the structural and functional elements within TADs remain challenging.

CTCF is a nuclear protein initially discovered for its role in enhancer-promoter insulation. It has been shown to play a role in genome architecture and in fact, its DNA binding sites are enriched at the borders of chromatin domains. Recently, we showed that depletion of CTCF impairs the DNA damage response to ionizing radiation.

2021年8月27日 · We exploited the M- to G1-phase progression to interrogate the contributions of the architectural factor CTCF and the process of transcription to genome re-sculpting in newborn nuclei. Depletion...

CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations of its ZFs.

2022年8月2日 · CCCTC-binding factor (CTCF), serving as the central organizer, plays a key role in 3D genome organization. CTCF is highly conserved across vertebrate species but absent in plants, C. elegans, and yeast [ 6 ].