2024年12月24日 · CISH (Cytokine Inducible SH2 Containing Protein) is a Protein Coding gene. Diseases associated with CISH include Bacteremia 2 and Malaria . Among its related pathways are IL3-mediated signaling events and Metabolism of proteins .

Fluorescence in situ hybridization (FISH) technologies enable rapid detection of chromosome aberrations in all manner of tissues, including both fresh and archival specimens. These technologies have gained broad acceptance in the clinical cytogenetic and research communities.

2020年8月6日 · Cytokine-inducible SH2-containing protein (CIS; encoded by the gene CISH) is a key negative regulator of interleukin-15 (IL-15) signaling in natural killer (NK) cells. Here, we develop human CISH-knockout (CISH -/-) NK cells using an induced pluripotent stem cell-derived NK cell (iPSC-NK cell) platform.

2010年6月3日 · Variants of CISH are associated with susceptibility to diseases caused by diverse infectious pathogens, suggesting that negative regulators of cytokine signaling have a role in immunity against...

2006年1月27日 · Chromogenic in-situ hybridization (CISH) is a relatively new method for determination of gene amplification using a peroxidase-based chromogenic reaction, which can be viewed using a...

Chromogenic in situ hybridization, or CISH, allows for detection of gene amplification, chromosome translocations, and chromosome number. CISH uses conventional peroxidase- or alkaline phosphatase-catalyzed reactions to stain 4-5 μm thick formalin-fixed, paraffin-embedded (FFPE) tissue sections.

In situ hybridization (ISH) is a powerful technique for localizing specific nucleic acid targets within fixed tissues and cells, allowing you to obtain temporal and spatial information about gene expression and genetic loci.

CISH is a highly sensitive and reliable method for detecting macrolide-resistant H. pylori in formalin-fixed, paraffin-embedded biopsy specimens, which represents the routine method of processing tissue obtained upon gastroscopy.

Cish, participates within a multi-molecular E3 ubiquitin ligase complex, which ubiquitinates target proteins. It has an inhibitory effect on T cell activation mediated by PLC-γ1 regulation, and it functions as a potent checkpoint in CD8 + T cell tumor immunotherapy.

In situ hybridization (ISH) allows evaluation of genetic abnormalities, such as changes in chromosome number, chromosome translocations, or gene amplifications, by hybridization of tagged DNA (or RNA) probes with complementary DNA (or RNA) sequences in interphase nuclei of target tissue.