CIITA is a human gene which encodes a protein called the class II, major histocompatibility complex, transactivator. [5] Mutations in this gene are responsible for the bare lymphocyte syndrome in which the immune system is severely compromised and …

2024年12月24日 · CIITA (Class II Major Histocompatibility Complex Transactivator) is a Protein Coding gene. Diseases associated with CIITA include Mhc Class Ii Deficiency 1 and Mhc Class Ii Deficiency. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Cytokine Signaling in Immune system.

The CIITA gene provides instructions for making a protein that primarily helps control the activity (transcription) of genes called major histocompatibility complex (MHC) class II genes. Learn about this gene and related health conditions.

2025年3月8日 · Gene target information for CIITA - class II major histocompatibility complex transactivator (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2023年10月1日 · In this review, we will focus on the MHC class II transactivator (CIITA), the master regulator of MHC class II (MHC-II) gene expression and the founding member of NLR.

2013年12月20日 · Class II transactivator (CIITA) is a transcriptional coactivator that regulates γ-interferon-activated transcription of Major Histocompatibility Complex (MHC) class I and II genes.

2021年1月22日 · In this review, we discuss the major histocompatibility complex (MHC) class II transactivator (CIITA), which is the master regulator of MHC class II gene expression.

2011年3月2日 · Here we show a highly expressed gene fusion involving the major histocompatibility complex (MHC) class II transactivator CIITA (MHC2TA) in KM-H2 cells.

Class II transactivator (CIITA) is a transcriptional coactivator that regulates γ-interferon-activated transcription of Major Histocompatibility Complex (MHC) class I and II genes. As such, it plays a critical role in immune responses: CIITA ...

CIITA is a highly regulated transactivator that governs all spatial, temporal, and quantitative aspects of MHC-II expression. It has been proposed to act as a non-DNA-binding transcriptional coactivator, but evidence that it actually functions at the level of MHC-II promoters was lacking.