Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene. [5][6][7] CHD4 is the core nucleosome-remodelling component of the Nucleosome Remodelling and Deacetylase (NuRD) complex. [8][9][10] The product of this gene belongs to the SNF2/RAD54 helicase family.

2020年9月3日 · CHD4 neurodevelopmental disorder (CHD4 -NDD) is associated with developmental delay, speech delay, and usually mild-to-moderate intellectual disability. Variability between individuals with CHD4 -NDD is significant, and a few have normal intelligence.

2024年12月24日 · CHD4 (Chromodomain Helicase DNA Binding Protein 4) is a Protein Coding gene. Diseases associated with CHD4 include Sifrim-Hitz-Weiss Syndrome and Pallister-Hall Syndrome. Among its related pathways are RNA Polymerase I Promoter Opening and PIP3 activates AKT signaling.

2019年8月7日 · In this study, we investigated the clinical spectrum of the disorder, genotype–phenotype correlations, and the effect of different missense variants on CHD4 function.

The CHD4 (chromodomain-helicase-DNA-binding 4) (or Mi-2β) protein is a founding component of the NuRD (nucleosome remodelling and deacetylation) complex. NuRD has long been known to function in transcriptional regulation, and is conserved throughout ...

2022年12月6日 · CHD4 is an essential, widely conserved ATP-dependent translocase that is also a broad tumour dependency. In common with other SF2-family chromatin remodelling enzymes, it alters chromatin...

CHD4 mediates proliferation and migration of non-small cell lung cancer via the RhoA/ROCK pathway by regulating PHF5A. Chd4 choreographs self-antigen expression for central immune tolerance. CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma.