Cluster of differentiation 86 (CD86), also known as B7-2, is a molecule expressed on antigen-presenting cells that provides the costimulatory signals required for T cell activation and survival. CD86 binds to two ligands on the surface of T cells: ...

2024年12月24日 · CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Plague and Cowpox . Among its related pathways are CD28 co-stimulation and Constitutive Signaling by Aberrant PI3K in Cancer .

Current perceptions are based around the concept that CD86 is the initial co-stimulatory ligand based on its more abundant and earlier expression pattern; CD80 has a role following antigen-presenting-cell activation.

CD80 and CD86 expressed by antigen-presenting cells (APCs) have different structural organisations. CD80 is a bivalent dimer (two binding sites) and CD86 is a monomer (single binding site). CD152 is also a bivalent dimer (two binding sites) whereas CD28 is a monovalent (single binding site) dimer.

CD86 refers to a 70-kDa glycoprotein consisting of 329 amino acids, a transmembrane region, and a longer cytoplasmic domain. It is expressed on various immune cells such as interdigitating DCs, Langerhans cells, B cells, and macrophages.

2023年4月7日 · CD86 appears to participate in immune invasion in AML and is an important player in the tumor microenvironment in this malignancy. At the same time, the IRS score developed by us has a good effect and may provide some support for the diagnosis of AML.

Our data suggest that CD86 exploits a different approach, where its low-affinity monomeric interaction becomes advantageous. After TE, CD86 and CTLA-4 dissociate, permitting unmodified CTLA-4 to be recycled and compensating for the intrinsically weak interaction.

CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4.

2024年3月5日 · Silencing of CD86 in dendritic cells by small interfering RNA regulates cytokine production in T cells from patients with allergic rhinitis in vitro. Sun R, Yang Y, Gu Z, Tang X, Zhang C, Kou W, Wei PSun R, et al .

2012年5月24日 · Environmental cues probably dictate CD86 expression, as suggested by the fact that rigorously sorted CD86 − HSCs generated CD86 + stem/progenitors when transplanted to lethally irradiated recipients.